Osteoblasts sense extracellular levels of phosphate to control the local expression of phosphatases for matrix mineralisation

Osteoblasts sense extracellular levels of phosphate to control the local expression of phosphatases for matrix mineralisation

The provision of inorganic phosphate (Pi) for biomineralisation is under systemic and local control. Locally, osteoblast production of phosphatases such as tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 is required for normal skeletal mineralisation and osteoblasts may sense extracellul...

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Bibliographic Details
Main Authors: Soher Nagi Jayash, Thomas Duff, Qaisar Tanveer, Worachet Promruk, Colin Farquharson
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Bone Reports
Subjects:
Osteoblast
Phosphate
Mineralisation
PHOSPHO1
Tissue-nonspecific alkaline phosphatase
Type III Na- Pi co-transporters
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187225000403
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