Bone marrow-derived myeloid cells drive neuroinflammation in Alzheimer's disease: Insights from the FAD4T mouse model

Bone marrow-derived myeloid cells drive neuroinflammation in Alzheimer's disease: Insights from the FAD4T mouse model

Objective: Alzheimer's disease (AD) is marked by amyloid β (Aβ) accumulation, neuroinflammation, and cognitive decline. While neuroinflammation is a key feature of AD, the potential involvement of bone marrow-derived cells in its pathology remains unclear. This study aimed to investigate the ro...

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Bibliographic Details
Main Authors: Yidan Pang, Dongjing Jia, Fang Ye, Fei Liu, Jiaqi Li, Siyuan Zhu, Bingqi Wang, Meng Yao, Lin Du, Chunying Yang, Guoji Guo, Cunxiang Ju, Lufeng Yao, Changqing Zhang, Junjie Gao, Hao Qi
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Orthopaedic Translation
Subjects:
Alzheimer's disease
Brain
Bone
Bone marrow
Myeloid cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X2500107X
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