Association between nighttime sleep duration and cognitive function in middle-aged and older adult patients with multimorbidity: the mediating role of depression
ObjectiveTo investigate the mediating role of depression in the relationship between nighttime sleep duration and cognitive function among middle-aged and older adult patients with multimorbidity, providing insights for mitigating cognitive decline.MethodsUtilizing data from the China Health and Ret...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1576629/full |
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| Summary: | ObjectiveTo investigate the mediating role of depression in the relationship between nighttime sleep duration and cognitive function among middle-aged and older adult patients with multimorbidity, providing insights for mitigating cognitive decline.MethodsUtilizing data from the China Health and Retirement Longitudinal Study (CHARLS) (2015 and 2020 waves), 4,210 participants with ≥2 chronic conditions were included. Correlation, regression, and mediation analyses were conducted to examine associations between sleep duration, depression, and cognitive function.ResultsThe prevalence of cognitive impairment was 35.7%. Nighttime sleep duration showed a weak positive correlation with cognitive function (r = 0.071, p < 0.01) and a stronger negative correlation with depression (r = −0.251, p < 0.01). Depression was negatively correlated with cognitive function (r = −0.262, p < 0.01). Mediation analysis revealed that depression fully mediated the sleep-cognition relationship [indirect effect: 0.120, 95% CI (0.100–0.141); direct effect nonsignificant].ConclusionDepression fully mediates the association between nighttime sleep duration and cognitive function in multimorbidity patients. Interventions targeting sleep hygiene and mental health may synergistically alleviate cognitive decline in this population. |
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| ISSN: | 2296-2565 |