Structural modeling of NAD+ binding modes to PARP-1

Structural modeling of NAD+ binding modes to PARP-1

The nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) plays an important role in the signaling and repair of DNA. PARP-1 catalyses covalent binding of poly (ADP-ribose) polymers with itself as well as with other acceptor proteins using NAD+ as a donor of ADP-ribose. Inhibitors of poly (ADP-rib...

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Bibliographic Details
Main Authors: N. V. Ivanisenko, D. A. Zhechev, V. A. Ivanisenko
Format: Article
Language:English
Published: Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders 2017-02-01
Series:Вавиловский журнал генетики и селекции
Subjects:
parp-1
nad+
structural model
Online Access:https://vavilov.elpub.ru/jour/article/view/861
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