Gut Microbiota and Neurovascular Patterns in Amnestic Mild Cognitive Impairment
<b>Background/Objectives:</b> The interplay between the gut microbiome (GMB) and neurovascular function in neurodegeneration is unclear. The goal of this proof-of-concept, cross-sectional study is to identify relationships between the GMB, neurovascular functioning, and cognition in amne...
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2025-05-01
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| author | Alexis B. Kazen Laura Glass Umfleet Fatima A. Aboulalazm Alexander D. Cohen Scott Terhune Lilly Mason Shawn Obarski Malgorzata Franczak Tammy Lyn Kindel Yang Wang John R. Kirby |
| author_facet | Alexis B. Kazen Laura Glass Umfleet Fatima A. Aboulalazm Alexander D. Cohen Scott Terhune Lilly Mason Shawn Obarski Malgorzata Franczak Tammy Lyn Kindel Yang Wang John R. Kirby |
| author_sort | Alexis B. Kazen |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> The interplay between the gut microbiome (GMB) and neurovascular function in neurodegeneration is unclear. The goal of this proof-of-concept, cross-sectional study is to identify relationships between the GMB, neurovascular functioning, and cognition in amnestic mild cognitive impairment (aMCI), the prototypical prodromal symptomatic stage of Alzheimer’s disease (AD). <b>Methods:</b> Participants (<i>n</i> = 14 aMCI and 10 controls) provided fecal samples for GMB sequencing (16S and shotgun metagenomics), underwent MRI, and completed cognitive testing. Cerebral vascular reactivity (CVR), cerebral blood flow (CBF), and arterial transit time (ATT) were assessed. Statistical analyses evaluated the relationships between discriminatory taxa, cerebrovascular metrics, and cognition. <b>Results:</b> Sequencing revealed differentially abundant bacterial and viral taxa distinguishing aMCI from controls. Spearman correlations revealed that bacteria known to induce inflammation were negatively associated with CVR, CBF, and cognition, and positively associated with ATT. A reciprocal pattern emerged for the association of taxa with gut health. <b>Conclusions:</b> Our results provide preliminary evidence that pro-inflammatory gut bacterial and viral taxa are associated with neurovascular dysfunction and cognitive impairment in prodromal AD, highlighting their potential as candidate microbial biomarkers and targets for early intervention. |
| format | Article |
| id | doaj-art-6b1d87df75324f49a149a103650d214d |
| institution | Matheson Library |
| issn | 2076-3425 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Brain Sciences |
| spelling | doaj-art-6b1d87df75324f49a149a103650d214d2025-06-25T13:34:55ZengMDPI AGBrain Sciences2076-34252025-05-0115653810.3390/brainsci15060538Gut Microbiota and Neurovascular Patterns in Amnestic Mild Cognitive ImpairmentAlexis B. Kazen0Laura Glass Umfleet1Fatima A. Aboulalazm2Alexander D. Cohen3Scott Terhune4Lilly Mason5Shawn Obarski6Malgorzata Franczak7Tammy Lyn Kindel8Yang Wang9John R. Kirby10Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Radiology, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA<b>Background/Objectives:</b> The interplay between the gut microbiome (GMB) and neurovascular function in neurodegeneration is unclear. The goal of this proof-of-concept, cross-sectional study is to identify relationships between the GMB, neurovascular functioning, and cognition in amnestic mild cognitive impairment (aMCI), the prototypical prodromal symptomatic stage of Alzheimer’s disease (AD). <b>Methods:</b> Participants (<i>n</i> = 14 aMCI and 10 controls) provided fecal samples for GMB sequencing (16S and shotgun metagenomics), underwent MRI, and completed cognitive testing. Cerebral vascular reactivity (CVR), cerebral blood flow (CBF), and arterial transit time (ATT) were assessed. Statistical analyses evaluated the relationships between discriminatory taxa, cerebrovascular metrics, and cognition. <b>Results:</b> Sequencing revealed differentially abundant bacterial and viral taxa distinguishing aMCI from controls. Spearman correlations revealed that bacteria known to induce inflammation were negatively associated with CVR, CBF, and cognition, and positively associated with ATT. A reciprocal pattern emerged for the association of taxa with gut health. <b>Conclusions:</b> Our results provide preliminary evidence that pro-inflammatory gut bacterial and viral taxa are associated with neurovascular dysfunction and cognitive impairment in prodromal AD, highlighting their potential as candidate microbial biomarkers and targets for early intervention.https://www.mdpi.com/2076-3425/15/6/538microbiomeviromeAlzheimer’s diseaseshotgun metagenomicsneurovascular dysfunctionneurodegeneration |
| spellingShingle | Alexis B. Kazen Laura Glass Umfleet Fatima A. Aboulalazm Alexander D. Cohen Scott Terhune Lilly Mason Shawn Obarski Malgorzata Franczak Tammy Lyn Kindel Yang Wang John R. Kirby Gut Microbiota and Neurovascular Patterns in Amnestic Mild Cognitive Impairment Brain Sciences microbiome virome Alzheimer’s disease shotgun metagenomics neurovascular dysfunction neurodegeneration |
| title | Gut Microbiota and Neurovascular Patterns in Amnestic Mild Cognitive Impairment |
| title_full | Gut Microbiota and Neurovascular Patterns in Amnestic Mild Cognitive Impairment |
| title_fullStr | Gut Microbiota and Neurovascular Patterns in Amnestic Mild Cognitive Impairment |
| title_full_unstemmed | Gut Microbiota and Neurovascular Patterns in Amnestic Mild Cognitive Impairment |
| title_short | Gut Microbiota and Neurovascular Patterns in Amnestic Mild Cognitive Impairment |
| title_sort | gut microbiota and neurovascular patterns in amnestic mild cognitive impairment |
| topic | microbiome virome Alzheimer’s disease shotgun metagenomics neurovascular dysfunction neurodegeneration |
| url | https://www.mdpi.com/2076-3425/15/6/538 |
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