In vitro Cytotoxicity of Nitroxyl Radicals with Respect to Tumor and Diploid Human Cells and Estimation of Their Antiviral Activity

In vitro Cytotoxicity of Nitroxyl Radicals with Respect to Tumor and Diploid Human Cells and Estimation of Their Antiviral Activity

Thirty nine water soluble nitroxyl radicals of various classes, belonging to piperidine, pyrrolidine and imidazolidine series were synthesized. Twenty seven of them were cytotoxic in vitro with respect to the tumor cell culture A431. The CC50 of the most active nitroxyl radicals with respect to cell...

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Bibliographic Details
Main Authors: I. A. Kirilyuk, V. A. Svyatchenko, D. A. Morozov, E. I. Kazachinskaya, N. N. Kiselev, S. M. Bakunova, M. A. Voinov, V. B. Loktev, I. A. Grigoryev
Format: Article
Language:Russian
Published: LLC "Publishing House OKI" 2020-05-01
Series:Антибиотики и Химиотерапия
Subjects:
nitroxyl radicals
cytotoxicity
antiviral activity
tumor cells
Online Access:https://www.antibiotics-chemotherapy.ru/jour/article/view/415
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