Innovative Nanocomposite Resins in Implants, Pain Management, and Post-Operative Care: Bridging Durability with Antimicrobial Technology by Meta-Analysis
Background: Dental resins are widely available in clinical practice, but they are susceptible to microbial colonization. Nanotechnology is used as a potential solution to simultaneously enhance mechanical stability and antimicrobial efficacy for pain management. This study assessed the antimicrobia...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
ziauddin University
2025-07-01
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| Series: | Pakistan Journal of Medicine and Dentistry |
| Subjects: | |
| Online Access: | https://ojs.zu.edu.pk/pjmd/article/view/3953 |
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| Summary: | Background: Dental resins are widely available in clinical practice, but they are susceptible to microbial colonization. Nanotechnology is used as a potential solution to simultaneously enhance mechanical stability and antimicrobial efficacy for pain management. This study assessed the antimicrobial effectiveness of nanocomposite dental resins in pain management using a systematic review and meta-analysis of in vitro studies.
Methods: Ten in vitro studies that adhered to the PRISMA 2020 guidelines were included in the systematic review. PubMed, Scopus, Web of Science, and Google Scholar databases until March 2025 were used. Risk of bias was calculated using the QUIN Tool. The data analysis involved pooling standardized mean differences with 95% confidence intervals (CIs) using RevMan version 5.4.1. The study authors conducted sensitivity and subgroup analyses.
Results: Ten in vitro studies were included, assessing 815 specimens. Meta-analysis showed a significant antimicrobial effect of nanocomposite resins against Streptococcus mutans (SMD = -8.84; 95% CI: -20.01 to 2.32; I² = 87%) and Candida albicans (SMD = -3.34; 95% CI: -4.65 to -2.03; I² < 50%). There was low risk of bias across all studies (scores 16–18/24 on QUIN), and the GRADE assessment verdicted moderate certainty of evidence mainly because of in vitro design and methodological variability.
Discussion: According to findings, nanocomposite resins had strong antimicrobial properties without undergoing any form of structural deterioration. Although the observed results showed promise for clinical application, further standardized testing procedures and animal testing would be required to attain broader adoption.
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| ISSN: | 2313-7371 2308-2593 |