The peculiarities of eosinophil apoptosis damage in patients with severe therapy-resistant bronchial asthma
The study aim: to investigate the dynamics of transcription factor p53, proapoptoic (bax, bcl-XS), antiapoptotic (bcl-2, bcl-XL) effectors, IL-5 expression in peripheral blood eosinophils of patients with severe therapy-resistant bronchial asthma (BA). Methods: clinical, functional, allergologic obs...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2005-12-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3697 |
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| Summary: | The study aim: to investigate the dynamics of transcription factor p53, proapoptoic (bax, bcl-XS), antiapoptotic (bcl-2, bcl-XL) effectors, IL-5 expression in peripheral blood eosinophils of patients with severe therapy-resistant bronchial asthma (BA). Methods: clinical, functional, allergologic observation, the study of apoptosis effectors expression (Polymerase Chain Reaction). Material: 60 patients with severe BA. Results: low p53 expression and eosinophils apoptosis depression were revealed in therapy-resistant asthmatics. Conclusion: eosinophil apoptosis disregulation – the key mechanism of persistent inflammation of the airways in therapy-resistant BA. |
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| ISSN: | 1682-0363 1819-3684 |