100-Day Mission for Future Pandemic Vaccines, Viewed Through the Lens of Low- and Middle-Income Countries (LMICs)
The 100-Day Mission, coordinated by the Coalition for Epidemic Preparedness Innovations (CEPI) and endorsed by significant international stakeholders, aims to shorten the timeframe for developing and implementing vaccines to 100 days after the report of a new pathogen. This ambitious goal is outline...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/13/7/773 |
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| author | Yodira Guadalupe Hernandez-Ruiz Erika Zoe Lopatynsky-Reyes Rolando Ulloa-Gutierrez María L. Avila-Agüero Alfonso J. Rodriguez-Morales Jessabelle E. Basa Frederic W. Nikiema Enrique Chacon-Cruz |
| author_facet | Yodira Guadalupe Hernandez-Ruiz Erika Zoe Lopatynsky-Reyes Rolando Ulloa-Gutierrez María L. Avila-Agüero Alfonso J. Rodriguez-Morales Jessabelle E. Basa Frederic W. Nikiema Enrique Chacon-Cruz |
| author_sort | Yodira Guadalupe Hernandez-Ruiz |
| collection | DOAJ |
| description | The 100-Day Mission, coordinated by the Coalition for Epidemic Preparedness Innovations (CEPI) and endorsed by significant international stakeholders, aims to shorten the timeframe for developing and implementing vaccines to 100 days after the report of a new pathogen. This ambitious goal is outlined as an essential first step in improving pandemic preparedness worldwide. This review highlights the mission’s implementation potential and challenges by examining it through the lens of low- and middle-income countries (LMICs), which often face barriers to equitable vaccine access. This article explores the scientific, economic, political, and social aspects that could influence the mission’s success, relying on lessons learned from previous pandemics, such as the Spanish flu, H1N1, and COVID-19. We also examined important cornerstones like prototype vaccine libraries, accelerated clinical trial preparedness, early biomarkers identification, scalable manufacturing capabilities, and rapid pathogen characterization. The review also explores the World Health Organization (WHO) Pandemic Agreement and the significance of Phase 4 surveillance in ensuring vaccine safety. We additionally evaluate societal issues that disproportionately impact LMICs, like vaccine reluctance, health literacy gaps, and digital access limitations. Without intentional attempts to incorporate under-resourced regions into global preparedness frameworks, we argue that the 100-Day Mission carries the risk of exacerbating already-existing disparities. Ultimately, our analysis emphasizes that success will not only rely on a scientific innovation but also on sustained international collaboration, transparent governance, and equitable funding that prioritizes inclusion from the beginning. |
| format | Article |
| id | doaj-art-694a7c25c82b49e08d8207a8a75f9cc6 |
| institution | Matheson Library |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-694a7c25c82b49e08d8207a8a75f9cc62025-07-25T13:38:30ZengMDPI AGVaccines2076-393X2025-07-0113777310.3390/vaccines13070773100-Day Mission for Future Pandemic Vaccines, Viewed Through the Lens of Low- and Middle-Income Countries (LMICs)Yodira Guadalupe Hernandez-Ruiz0Erika Zoe Lopatynsky-Reyes1Rolando Ulloa-Gutierrez2María L. Avila-Agüero3Alfonso J. Rodriguez-Morales4Jessabelle E. Basa5Frederic W. Nikiema6Enrique Chacon-Cruz7Escuela de Medicina, Universidad de Monterrey, San Pedro Garza García, Nuevo León 66238, MexicoThink Vaccines LLC., Houston, TX 77005, USAServicio de Aislamiento Pediatría, Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera”, San José 1654-1000, Costa RicaServicio de Infectología, Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera”, San José 10905, Costa RicaFaculty of Health Sciences, Universidad Científica del Sur, Lima 15307, PeruResearch Institute for Tropical Medicine, Muntinlupa City 2428, Metro Manila, PhilippinesInstitut de Recherche en Sciences de la Santé, Direction Régionale de l’Ouest, 399 Avenue de la Liberté, Bobo-Dioulasso 01, Hauts-Bassins 0P1 BP 545, Burkina FasoThink Vaccines LLC., Houston, TX 77005, USAThe 100-Day Mission, coordinated by the Coalition for Epidemic Preparedness Innovations (CEPI) and endorsed by significant international stakeholders, aims to shorten the timeframe for developing and implementing vaccines to 100 days after the report of a new pathogen. This ambitious goal is outlined as an essential first step in improving pandemic preparedness worldwide. This review highlights the mission’s implementation potential and challenges by examining it through the lens of low- and middle-income countries (LMICs), which often face barriers to equitable vaccine access. This article explores the scientific, economic, political, and social aspects that could influence the mission’s success, relying on lessons learned from previous pandemics, such as the Spanish flu, H1N1, and COVID-19. We also examined important cornerstones like prototype vaccine libraries, accelerated clinical trial preparedness, early biomarkers identification, scalable manufacturing capabilities, and rapid pathogen characterization. The review also explores the World Health Organization (WHO) Pandemic Agreement and the significance of Phase 4 surveillance in ensuring vaccine safety. We additionally evaluate societal issues that disproportionately impact LMICs, like vaccine reluctance, health literacy gaps, and digital access limitations. Without intentional attempts to incorporate under-resourced regions into global preparedness frameworks, we argue that the 100-Day Mission carries the risk of exacerbating already-existing disparities. Ultimately, our analysis emphasizes that success will not only rely on a scientific innovation but also on sustained international collaboration, transparent governance, and equitable funding that prioritizes inclusion from the beginning.https://www.mdpi.com/2076-393X/13/7/773vaccinespandemic100-day planCEPI |
| spellingShingle | Yodira Guadalupe Hernandez-Ruiz Erika Zoe Lopatynsky-Reyes Rolando Ulloa-Gutierrez María L. Avila-Agüero Alfonso J. Rodriguez-Morales Jessabelle E. Basa Frederic W. Nikiema Enrique Chacon-Cruz 100-Day Mission for Future Pandemic Vaccines, Viewed Through the Lens of Low- and Middle-Income Countries (LMICs) Vaccines vaccines pandemic 100-day plan CEPI |
| title | 100-Day Mission for Future Pandemic Vaccines, Viewed Through the Lens of Low- and Middle-Income Countries (LMICs) |
| title_full | 100-Day Mission for Future Pandemic Vaccines, Viewed Through the Lens of Low- and Middle-Income Countries (LMICs) |
| title_fullStr | 100-Day Mission for Future Pandemic Vaccines, Viewed Through the Lens of Low- and Middle-Income Countries (LMICs) |
| title_full_unstemmed | 100-Day Mission for Future Pandemic Vaccines, Viewed Through the Lens of Low- and Middle-Income Countries (LMICs) |
| title_short | 100-Day Mission for Future Pandemic Vaccines, Viewed Through the Lens of Low- and Middle-Income Countries (LMICs) |
| title_sort | 100 day mission for future pandemic vaccines viewed through the lens of low and middle income countries lmics |
| topic | vaccines pandemic 100-day plan CEPI |
| url | https://www.mdpi.com/2076-393X/13/7/773 |
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