Impact of sleep deprivation on creatine metabolism biomarkers in healthy young males
Background Creatine is a crucial component of cellular energy metabolism, facilitating ATP regeneration to support high energy demands. While its therapeutic potential, particularly in neuroprotection, is well-recognized, its response to stress conditions such as sleep deprivation remains insufficie...
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Taylor & Francis Group
2025-09-01
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| Serier: | Journal of the International Society of Sports Nutrition |
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| Online adgang: | https://www.tandfonline.com/doi/10.1080/15502783.2025.2533643 |
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| author | Nikola Todorovic David Nedeljkovic Jovana Panic Sergej M. Ostojic |
| author_facet | Nikola Todorovic David Nedeljkovic Jovana Panic Sergej M. Ostojic |
| author_sort | Nikola Todorovic |
| collection | DOAJ |
| description | Background Creatine is a crucial component of cellular energy metabolism, facilitating ATP regeneration to support high energy demands. While its therapeutic potential, particularly in neuroprotection, is well-recognized, its response to stress conditions such as sleep deprivation remains insufficiently investigated. This study examines the effects of sleep deprivation on creatine metabolism in healthy young males.Methods Sixteen healthy young male participants (age: 25.3 ± 4.7 years; body mass: 81.6 ± 8.8 kg) were recruited to assess the impact of 24-hour sleep deprivation on biomarkers of creatine metabolism. Primary outcomes included serum levels of creatine, guanidinoacetic acid (GAA), and creatinine, measured at baseline and after 24 hours.Results Sleep deprivation significantly increased serum creatine levels, rising from 48.63 ± 27.05 μmol/L at baseline to 63.84 ± 23.83 μmol/L after 24 hours (95% CI: −29.14 to −1.27; P = 0.03), with a moderate to large effect size (Cohen’s d = 0.59). Serum GAA levels showed a non-significant increase, from 3.27 ± 0.60 μmol/L to 3.47 ± 0.64 μmol/L (95% CI: −0.58 to 0.16; P = 0.26; Cohen’s d = 0.32). Serum creatinine levels remained unchanged, with no significant difference between baseline (100.57 ± 9.19 μmol/L) and follow-up (106.10 ± 27.90 μmol/L; 95% CI: −21.24 to 10.20; P = 0.46; Cohen’s d = 0.26).Conclusion Sleep deprivation alters creatine metabolism biomarkers, indicating shifts in metabolic pathways. Further research is necessary to validate and expand these findings, potentially elucidating the role of creatine in stress-related conditions. |
| format | Article |
| id | doaj-art-690bae6995844aa79cb2acf94a0dfd21 |
| institution | Matheson Library |
| issn | 1550-2783 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of the International Society of Sports Nutrition |
| spelling | doaj-art-690bae6995844aa79cb2acf94a0dfd212025-07-26T07:13:16ZengTaylor & Francis GroupJournal of the International Society of Sports Nutrition1550-27832025-09-0122sup110.1080/15502783.2025.2533643Impact of sleep deprivation on creatine metabolism biomarkers in healthy young malesNikola Todorovic0David Nedeljkovic1Jovana Panic2Sergej M. Ostojic3University of Novi Sad, Applied Bioenergetics Lab, Faculty of Sport and Physical Education, Novi Sad, SerbiaUniversity of Novi Sad, Applied Bioenergetics Lab, Faculty of Sport and Physical Education, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Sciences, Novi Sad, SerbiaUniversity of Novi Sad, Applied Bioenergetics Lab, Faculty of Sport and Physical Education, Novi Sad, SerbiaBackground Creatine is a crucial component of cellular energy metabolism, facilitating ATP regeneration to support high energy demands. While its therapeutic potential, particularly in neuroprotection, is well-recognized, its response to stress conditions such as sleep deprivation remains insufficiently investigated. This study examines the effects of sleep deprivation on creatine metabolism in healthy young males.Methods Sixteen healthy young male participants (age: 25.3 ± 4.7 years; body mass: 81.6 ± 8.8 kg) were recruited to assess the impact of 24-hour sleep deprivation on biomarkers of creatine metabolism. Primary outcomes included serum levels of creatine, guanidinoacetic acid (GAA), and creatinine, measured at baseline and after 24 hours.Results Sleep deprivation significantly increased serum creatine levels, rising from 48.63 ± 27.05 μmol/L at baseline to 63.84 ± 23.83 μmol/L after 24 hours (95% CI: −29.14 to −1.27; P = 0.03), with a moderate to large effect size (Cohen’s d = 0.59). Serum GAA levels showed a non-significant increase, from 3.27 ± 0.60 μmol/L to 3.47 ± 0.64 μmol/L (95% CI: −0.58 to 0.16; P = 0.26; Cohen’s d = 0.32). Serum creatinine levels remained unchanged, with no significant difference between baseline (100.57 ± 9.19 μmol/L) and follow-up (106.10 ± 27.90 μmol/L; 95% CI: −21.24 to 10.20; P = 0.46; Cohen’s d = 0.26).Conclusion Sleep deprivation alters creatine metabolism biomarkers, indicating shifts in metabolic pathways. Further research is necessary to validate and expand these findings, potentially elucidating the role of creatine in stress-related conditions.https://www.tandfonline.com/doi/10.1080/15502783.2025.2533643Inadequate sleepcreatinebiomarkersmetabolism |
| spellingShingle | Nikola Todorovic David Nedeljkovic Jovana Panic Sergej M. Ostojic Impact of sleep deprivation on creatine metabolism biomarkers in healthy young males Journal of the International Society of Sports Nutrition Inadequate sleep creatine biomarkers metabolism |
| title | Impact of sleep deprivation on creatine metabolism biomarkers in healthy young males |
| title_full | Impact of sleep deprivation on creatine metabolism biomarkers in healthy young males |
| title_fullStr | Impact of sleep deprivation on creatine metabolism biomarkers in healthy young males |
| title_full_unstemmed | Impact of sleep deprivation on creatine metabolism biomarkers in healthy young males |
| title_short | Impact of sleep deprivation on creatine metabolism biomarkers in healthy young males |
| title_sort | impact of sleep deprivation on creatine metabolism biomarkers in healthy young males |
| topic | Inadequate sleep creatine biomarkers metabolism |
| url | https://www.tandfonline.com/doi/10.1080/15502783.2025.2533643 |
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