Fucoxanthin inhibits the proliferation of MOLM13 cells by targeting AKT to disrupt glucose metabolism

Fucoxanthin inhibits the proliferation of MOLM13 cells by targeting AKT to disrupt glucose metabolism

Fucoxanthin is a natural carotenoid that has remarkable anti-tumor effects and an excellent safety profile. Here, we combined molecular docking, dynamics simulations, and functional assays (CCK-8, flow cytometry, glucose/ATP detection) to decipher the mechanism of Fucoxanthin on FLT3-ITD AML cells....

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Bibliographic Details
Main Authors: Tingting Niu, Ying Chen, Mengmeng Sun, Cong Shi, Duobing Zou, Wei Wu, Yuzhan Chen, Juanjuan Chen, Haimin Chen, Guifang Ouyang, Qitian Mu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
fucoxanthin
acute myeloid leukemia
Akt
GLUT1
glucose metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1601281/full
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