Global Longitudinal Strain (GLS) in Elderly and Its Associated Factors
Background: cardiovascular disease is very common and can be fatal in elderly patients. It is often preceded by asymptomatic or subclinical left ventricular systolic dysfunction (LVSD). Early detection of LVSD can reduce morbidity and mortality due to cardiovascular disease. One method used in the...
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Interna Publishing
2020-04-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | https://actamedindones.org/index.php/ijim/article/view/1187 |
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| author | Mohamad Syahrir Azizi Sally Aman Nasution Siti Setiati Hamzah Shatri |
| author_facet | Mohamad Syahrir Azizi Sally Aman Nasution Siti Setiati Hamzah Shatri |
| author_sort | Mohamad Syahrir Azizi |
| collection | DOAJ |
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Background: cardiovascular disease is very common and can be fatal in elderly patients. It is often preceded by asymptomatic or subclinical left ventricular systolic dysfunction (LVSD). Early detection of LVSD can reduce morbidity and mortality due to cardiovascular disease. One method used in the early detection of LVSD is an assessment of global longitudinal strain (GLS). This study aimed to determine the mean value of GLS and GLS-related factors. Methods: this cross-sectional study was conducted among elderly patients aged > 60 years in the geriatric and cardiology clinic, Internal Medicine, CMH Hospital. Data were obtained from interviews, medical records, and transthoracic echocardiography examination. The variables of age, frailty, hypertension, coronary artery disease, dyslipidemia, and diabetes mellitus were analyzed as the determinants of a decrease in GLS. Univariate analysis was conducted for each variable. Bivariate analysis was conducted using the chi-square test with a significance level of p<0.25 and confidence interval (CI) of 95%, and multivariate analysis used a logistic regression test. Results: a total of 194 patients were admitted according to the study criteria, with a mean age of 66 years. The proportion of women was 60.8%. The study revealed that the determinants with p<0.25 are frailty, hypertension, dyslipidemia, and diabetes mellitus, with multivariate analysis frailty having an OR of 2.002 (95% CI 1.042–3.925) and diabetes mellitus having an OR of 2.278 (95% CI 1.033–5.025). Conclusion: the mean value of GLS among the elderly was -21.6% (minimum value -5.3% and maximum value 29.9%). The factors that influence the decrease of GLS are frailty and diabetes mellitus.
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| format | Article |
| id | doaj-art-67ca8f97c8d842aebdf307f9c3d9f67f |
| institution | Matheson Library |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | Interna Publishing |
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| series | Acta Medica Indonesiana |
| spelling | doaj-art-67ca8f97c8d842aebdf307f9c3d9f67f2025-07-24T07:01:34ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322020-04-01521361Global Longitudinal Strain (GLS) in Elderly and Its Associated FactorsMohamad Syahrir Azizi0Sally Aman Nasution1Siti Setiati2Hamzah Shatri3Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia Background: cardiovascular disease is very common and can be fatal in elderly patients. It is often preceded by asymptomatic or subclinical left ventricular systolic dysfunction (LVSD). Early detection of LVSD can reduce morbidity and mortality due to cardiovascular disease. One method used in the early detection of LVSD is an assessment of global longitudinal strain (GLS). This study aimed to determine the mean value of GLS and GLS-related factors. Methods: this cross-sectional study was conducted among elderly patients aged > 60 years in the geriatric and cardiology clinic, Internal Medicine, CMH Hospital. Data were obtained from interviews, medical records, and transthoracic echocardiography examination. The variables of age, frailty, hypertension, coronary artery disease, dyslipidemia, and diabetes mellitus were analyzed as the determinants of a decrease in GLS. Univariate analysis was conducted for each variable. Bivariate analysis was conducted using the chi-square test with a significance level of p<0.25 and confidence interval (CI) of 95%, and multivariate analysis used a logistic regression test. Results: a total of 194 patients were admitted according to the study criteria, with a mean age of 66 years. The proportion of women was 60.8%. The study revealed that the determinants with p<0.25 are frailty, hypertension, dyslipidemia, and diabetes mellitus, with multivariate analysis frailty having an OR of 2.002 (95% CI 1.042–3.925) and diabetes mellitus having an OR of 2.278 (95% CI 1.033–5.025). Conclusion: the mean value of GLS among the elderly was -21.6% (minimum value -5.3% and maximum value 29.9%). The factors that influence the decrease of GLS are frailty and diabetes mellitus. https://actamedindones.org/index.php/ijim/article/view/1187global longitudinal strain (GLS)left ventricular systolic dysfunction (LVSD)frailty |
| spellingShingle | Mohamad Syahrir Azizi Sally Aman Nasution Siti Setiati Hamzah Shatri Global Longitudinal Strain (GLS) in Elderly and Its Associated Factors Acta Medica Indonesiana global longitudinal strain (GLS) left ventricular systolic dysfunction (LVSD) frailty |
| title | Global Longitudinal Strain (GLS) in Elderly and Its Associated Factors |
| title_full | Global Longitudinal Strain (GLS) in Elderly and Its Associated Factors |
| title_fullStr | Global Longitudinal Strain (GLS) in Elderly and Its Associated Factors |
| title_full_unstemmed | Global Longitudinal Strain (GLS) in Elderly and Its Associated Factors |
| title_short | Global Longitudinal Strain (GLS) in Elderly and Its Associated Factors |
| title_sort | global longitudinal strain gls in elderly and its associated factors |
| topic | global longitudinal strain (GLS) left ventricular systolic dysfunction (LVSD) frailty |
| url | https://actamedindones.org/index.php/ijim/article/view/1187 |
| work_keys_str_mv | AT mohamadsyahrirazizi globallongitudinalstrainglsinelderlyanditsassociatedfactors AT sallyamannasution globallongitudinalstrainglsinelderlyanditsassociatedfactors AT sitisetiati globallongitudinalstrainglsinelderlyanditsassociatedfactors AT hamzahshatri globallongitudinalstrainglsinelderlyanditsassociatedfactors |