Evaluation of the Antioxidant and Anticancer Effectiveness of Some New Metal Ions Complexes with Azo Dye: Synthesis and Characterization
This paper presents a new azo dye 3-[2-(1H-indol-2-yl)ethyldiazenyl]quinolin-2-ol] from the reaction of the diazonium salt derived from tryptamine and 2-hydroxyquinoline. Azo dye was used to prepare a series of complexes with the chlorides of Ni(II), Pt(IV), Pd(II), Cd(II), and Zn(II). Compounds wer...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Department of Chemistry, Universitas Gadjah Mada
2025-07-01
|
| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/104167 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839582624270516224 |
|---|---|
| author | Vian Yamin Jirjees Abbas Ali Al-Hamdan |
| author_facet | Vian Yamin Jirjees Abbas Ali Al-Hamdan |
| author_sort | Vian Yamin Jirjees |
| collection | DOAJ |
| description | This paper presents a new azo dye 3-[2-(1H-indol-2-yl)ethyldiazenyl]quinolin-2-ol] from the reaction of the diazonium salt derived from tryptamine and 2-hydroxyquinoline. Azo dye was used to prepare a series of complexes with the chlorides of Ni(II), Pt(IV), Pd(II), Cd(II), and Zn(II). Compounds were analyzed and characterized using elemental analysis, magnetic measurement, UV-vis, IR, MS, NMR, and conductivity. The findings demonstrated that the ligand acts as ionic in complex form, O-bidentate, supporting the proposed formula. The complexes generally exhibited tetrahedral and octahedral geometries, except the palladium complex, which adopted a square planar geometry. TGA was used to investigate the thermal characteristics of compounds. The ligand dissociated in a single step, whereas the complexes dissociated through multiple steps, exhibiting greater thermal stability than the ligand. This study explored the antioxidant and anticancer activities of compounds. The results indicate that compounds are more effective in scavenging free radicals, as measured by their IC50 values, and determined the order of inhibitory effect of compounds to be gallic acid > [Ni(L)2(H2O)2] > [Pt(L)2Cl2] > [Pd(L)2] >ligand > [Cd(L)2] > [Zn(L)2]. The ligand showed significant anticancer activity, with a lower IC50 value of 49.86 μg/mL than the complexes, indicating greater efficacy against cancer cells MCF-7. |
| format | Article |
| id | doaj-art-65b3ac632e8840e5a3f02a9583f671b2 |
| institution | Matheson Library |
| issn | 1411-9420 2460-1578 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj-art-65b3ac632e8840e5a3f02a9583f671b22025-08-04T04:24:54ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782025-07-012541132114210.22146/ijc.10416737725Evaluation of the Antioxidant and Anticancer Effectiveness of Some New Metal Ions Complexes with Azo Dye: Synthesis and CharacterizationVian Yamin Jirjees0Abbas Ali Al-Hamdan1Department of Chemistry, College of Science, University of Duhok, Kurdistan Region 42001, Duhok, IraqDepartment of Chemistry, College of Science for Women, University of Baghdad, Baghdad 10071, IraqThis paper presents a new azo dye 3-[2-(1H-indol-2-yl)ethyldiazenyl]quinolin-2-ol] from the reaction of the diazonium salt derived from tryptamine and 2-hydroxyquinoline. Azo dye was used to prepare a series of complexes with the chlorides of Ni(II), Pt(IV), Pd(II), Cd(II), and Zn(II). Compounds were analyzed and characterized using elemental analysis, magnetic measurement, UV-vis, IR, MS, NMR, and conductivity. The findings demonstrated that the ligand acts as ionic in complex form, O-bidentate, supporting the proposed formula. The complexes generally exhibited tetrahedral and octahedral geometries, except the palladium complex, which adopted a square planar geometry. TGA was used to investigate the thermal characteristics of compounds. The ligand dissociated in a single step, whereas the complexes dissociated through multiple steps, exhibiting greater thermal stability than the ligand. This study explored the antioxidant and anticancer activities of compounds. The results indicate that compounds are more effective in scavenging free radicals, as measured by their IC50 values, and determined the order of inhibitory effect of compounds to be gallic acid > [Ni(L)2(H2O)2] > [Pt(L)2Cl2] > [Pd(L)2] >ligand > [Cd(L)2] > [Zn(L)2]. The ligand showed significant anticancer activity, with a lower IC50 value of 49.86 μg/mL than the complexes, indicating greater efficacy against cancer cells MCF-7.https://jurnal.ugm.ac.id/ijc/article/view/104167anticancerantioxidantthermal analysisazo dye complexesmass spectra |
| spellingShingle | Vian Yamin Jirjees Abbas Ali Al-Hamdan Evaluation of the Antioxidant and Anticancer Effectiveness of Some New Metal Ions Complexes with Azo Dye: Synthesis and Characterization Indonesian Journal of Chemistry anticancer antioxidant thermal analysis azo dye complexes mass spectra |
| title | Evaluation of the Antioxidant and Anticancer Effectiveness of Some New Metal Ions Complexes with Azo Dye: Synthesis and Characterization |
| title_full | Evaluation of the Antioxidant and Anticancer Effectiveness of Some New Metal Ions Complexes with Azo Dye: Synthesis and Characterization |
| title_fullStr | Evaluation of the Antioxidant and Anticancer Effectiveness of Some New Metal Ions Complexes with Azo Dye: Synthesis and Characterization |
| title_full_unstemmed | Evaluation of the Antioxidant and Anticancer Effectiveness of Some New Metal Ions Complexes with Azo Dye: Synthesis and Characterization |
| title_short | Evaluation of the Antioxidant and Anticancer Effectiveness of Some New Metal Ions Complexes with Azo Dye: Synthesis and Characterization |
| title_sort | evaluation of the antioxidant and anticancer effectiveness of some new metal ions complexes with azo dye synthesis and characterization |
| topic | anticancer antioxidant thermal analysis azo dye complexes mass spectra |
| url | https://jurnal.ugm.ac.id/ijc/article/view/104167 |
| work_keys_str_mv | AT vianyaminjirjees evaluationoftheantioxidantandanticancereffectivenessofsomenewmetalionscomplexeswithazodyesynthesisandcharacterization AT abbasalialhamdan evaluationoftheantioxidantandanticancereffectivenessofsomenewmetalionscomplexeswithazodyesynthesisandcharacterization |