Expression characteristics, molecular mechanisms, and clinical significance of DICER1 in breast cancer

QR Code

Expression characteristics, molecular mechanisms, and clinical significance of DICER1 in breast cancer

ObjectiveThis study aims to investigate the expression patterns, molecular mechanisms, and clinical significance of DICER1 in breast cancer (BRCA), providing new biomarkers and therapeutic targets for prognosis assessment and personalized treatment of breast cancer.MethodsBy integrating RNA-seq data...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xi Zhang, Long Yu, Cuizhi Geng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Genetics
Subjects:	breast cancer (BrCa) DIcer1 tumor mutation burden (TMB) prognostic biomarker immune microenvironment drug sensitivity
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2025.1586287/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Clinical, molecular and radiological characteristics of thyroid nodules with somatic DICER1 mutations in adults
by: Ying Han, et al.
Published: (2025-06-01)

Point mutations of Dicer2 conferred Fusarium asiaticum resistance to RNAi-related biopesticide
by: Kaixin Gu, et al.
Published: (2025-02-01)

Dicer Is Involved in Cytotoxicity and Motor Impairment Induced by TBPH Deficiency
by: Xiang Long, et al.
Published: (2025-06-01)

Tumor immune microenvironment and apoptotic markers in breast cancer patients carrying <I>BRCA1</I> gene mutations
by: A. I. Stukan, et al.
Published: (2022-09-01)

Diagnosis and treatment of ovarian cancer in the light of modern molecular genetic achievements
by: E. M. Kagirova, et al.
Published: (2023-11-01)

Role of BRCA 1 и BRCA 2 gene mutations in the occurrence of male breast cancer
by: A. V. Bykova, et al.
Published: (2014-07-01)

Predictive and prognostic features of early and locally advanced <i>PIK3CA</i>-mutated luminal HER2-negative breast cancer
by: A. I. Stukan, et al.
Published: (2024-01-01)

Ethnic aspects of hereditary breast cancer
by: P. A. Gervas, et al.
Published: (2019-04-01)

Causes of resistance to PARP inhibitors and ways to overcome it. Case report of aggressive <i>BRCA</i>-related breast cancer
by: A. I. Stukan, et al.
Published: (2022-05-01)

BRCA1, BRCA2 mutations — future of predictive oncology: a review of literature
by: V. N. Dmitriev, et al.
Published: (2014-07-01)

Breast magnetic resonance imaging significance for breast cancer diagnostic in women with genetic predisposition and a strong family history
by: M. S. Karpova, et al.
Published: (2014-07-01)

LOSS OF HETEROZYGOSITY IN THE BRCA1 AND BRCA2 LOCUS IN BREAST CANCER
by: M. M. Tsyganov, et al.
Published: (2020-07-01)

Interplay between tumor mutation burden and the tumor microenvironment predicts the prognosis of pan-cancer anti-PD-1/PD-L1 therapy
by: Wuyuan Liao, et al.
Published: (2025-07-01)

Molecular biological subtypes of breast cancer in BRCA1 mutation carriers
by: N. I. Pospekhova, et al.
Published: (2021-01-01)

Breast cancer screening in germline mutation carriers. A literature review
by: A. V. Sultanbaev, et al.
Published: (2023-08-01)

CLINICAL AND MORPHOLOGICAL FEATURES OF HEREDITARY OVARIAN CANCER
by: K. B. Kotiv, et al.
Published: (2017-12-01)

DETECTION OF MUTATIONS RELATED TO HEREDITARY CANCER IN RELATIVES OF BREAST CANCER PATIENTS
by: G. A. Paul, et al.
Published: (2017-09-01)

REPARATION SYSTEM GENES: POPULATION DIFFERENCES IN HEREDITARY OVARIAN AND BREAST CANCER DETERMINED BY NEXT-GENERATION SEQUENCING
by: O. I. Brovkina, et al.
Published: (2017-06-01)

Molecular genetic markers of breast cancer
by: K. A. Grishina, et al.
Published: (2016-11-01)

Breast cancer risk factors assessment and BRCA-associated breast cancer evaluation in mammographic screening in India
by: S. K. Ternovoy, et al.
Published: (2014-07-01)

Genotype-phenotype correlations in patients with breast cancer and BRCA1 mutations (4153delA, 185delAG, 5382insC)
by: Ye. M. Bit-Sava, et al.
Published: (2014-07-01)

PIK3CA mutations in breast cancer with low HER2 / neu expression
by: I. A. Pavlenko, et al.
Published: (2022-12-01)

The prognostic significance of BRCA1 gene expression in patients with breast cancer
by: M. M. Tsyganov, et al.
Published: (2019-07-01)

Study of the Carrier State for Five BRCA1/BRCA2 Deleterious Mutations in Bulgarian Women with Breast Cancer
by: Katia Kovacheva, et al.
Published: (2013-12-01)

Prevalence of Five BRCA1/2 Mutations in Bulgarian Breast Cancer Patients
by: Katia Kovacheva, et al.
Published: (2019-01-01)

Prophylactic adnexectomy in BRCA1 and BRCA2 gene mutation carriers (а review of literature)
by: T. A. Shendrikova, et al.
Published: (2014-07-01)

Prognostic and predictive value of a novel 100-point scale in patients with T1–2N0M0 breast cancer
by: R. M. Paltuev, et al.
Published: (2023-06-01)

Results of a preliminary analysis of the pattern of hereditary breast cancer in the women of a Kyrgyz population
by: K. B. Makieva, et al.
Published: (2014-07-01)

Prevalence of germline BRCA1/2 pathogenic variants in unselected Korean patients with HER2-negative metastatic breast cancer: a nationwide prospective study (KCSG BR19-10)Research in context
by: Hee Kyung Ahn, et al.
Published: (2025-07-01)

Tactics of radiographic diagnostics of breast cancer in women with inherited predisposition
by: M. S. Karpova, et al.
Published: (2015-01-01)

Identification of the important role of CA9 in immune infiltration and prognosis in cervical cancer
by: Zhi Zhao, et al.
Published: (2025-12-01)

The role of biomarkers in the early diagnostics of breast cancer
by: A. Kh. Ismagilov, et al.
Published: (2021-03-01)

Identification of The Immune Subtype Among Muscle-invasive Bladder Cancer Patients by Multiple Datasets
by: Khyber Shinwari, et al.
Published: (2022-04-01)

Detection of BRCA1and BRCA2 mutation for Breast Cancer in Sample of Iraqi Women above 40 Years
by: Baghdad Science Journal
Published: (2010-03-01)

The spectrum of BRCA1 gene mutations in early onset breast cancer patients from Russia
by: M. S. Anisimenko, et al.
Published: (2018-09-01)

Mutations of the PIK3CA gene in patients with breast cancer in the Krasnoyarsk region
by: A. V. Zyuzyukina, et al.
Published: (2024-07-01)

A systematic review on the association between ovarian and prostate cancer with <I>BRCA1</I> and <I>BRCA2</I> gene
by: Sarpparajan Chitra Veena, et al.
Published: (2023-01-01)

Hereditary breast cancer: genetic and clinical hetergeneity, genetic testing, prophylactic surgery
by: L. N. Lyubchenko, et al.
Published: (2015-06-01)

HEREDITARY BREAST CANCER
by: E. M. Bit-Sava, et al.
Published: (2016-02-01)

Unveiling the Diagnostic Significance of Calprotectin in Serous Ovarian Carcinoma
by: Alkis Matsas, et al.
Published: (2025-07-01)