Abemaciclib induces G1 arrest and lysosomal dysfunction in canine melanoma cells: synergistic effects with fenbendazole

Abemaciclib induces G1 arrest and lysosomal dysfunction in canine melanoma cells: synergistic effects with fenbendazole

IntroductionAbemaciclib, a CDK4/6 inhibitor, is well-established for treating hormone receptor-positive and HER2-negative (HR+/HER2−) human breast cancer by inducing G1 cell cycle arrest. However, its antitumor effects in other cancers, including canine melanoma, remain largely unexplored. Canine me...

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Bibliographic Details
Main Authors: Se-Hoon Kim, Jun-Yeol Choi, Yoon-Ho Suh, Ki-Hoon Song, Min-Ok Ryu, Kyoung-Won Seo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Veterinary Science
Subjects:
autophagy
CDK4/6 inhibitor
combination therapy
G1 arrest
lysosomal dysfunction
senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1603686/full
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