Targeting poor solubility of docetaxel: Computational screening of ionic liquids using COSMO-RS

Targeting poor solubility of docetaxel: Computational screening of ionic liquids using COSMO-RS

Docetaxel (DTX), a chemotherapeutic agent widely used in cancer treatment, has limited therapeutic efficacy owing to its poor oral absorption and low bioavailability. This study aims to improve DTX solubility by predicting its compatibility with ionic liquids (ILs) using conductor-like screening mod...

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Bibliographic Details
Main Authors: Najihah Mohd Noor, Amal A.M. Elgharbawy, Huma Warsi Khan, Yumi Zuhanis Has-Yun Hashim, Muhammad Moniruzzaman, Mohd Firdaus Abd. Wahab, Hamzah Mohd Salleh, Siti Nur Idayu Matusin
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Journal of Ionic Liquids
Subjects:
Active pharmaceutical ingredients
COSMO-RS
Docetaxel
Ionic liquids
Solubility
Therapeutic agent
Online Access:http://www.sciencedirect.com/science/article/pii/S2772422025000370
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