Multi-omics in colorectal cancer liver metastasis: applications and research advances
Colorectal cancer (CRC) is a common malignant tumor with a high mortality rate worldwide. Advanced CRC often leads to liver metastasis, which has a poor prognosis, highlighting the need to investigate the underlying mechanisms. Omics, encompassing genomics, epigenomics, transcriptomics, proteomics,...
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2025-06-01
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| Series: | Cancer Biology & Medicine |
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| Online Access: | https://www.cancerbiomed.org/content/22/6/618 |
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| _version_ | 1839635129338691584 |
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| author | Kexue Zhou Chengxiang Yang Yan Li |
| author_facet | Kexue Zhou Chengxiang Yang Yan Li |
| author_sort | Kexue Zhou |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a common malignant tumor with a high mortality rate worldwide. Advanced CRC often leads to liver metastasis, which has a poor prognosis, highlighting the need to investigate the underlying mechanisms. Omics, encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics, enables comprehensive molecular analysis of cells and tissues. Tumor-omics research has advanced rapidly, with growing attention on CRC-related omics. However, systematic reviews on omics research specific to colorectal cancer liver metastasis (CRLM) are limited. This review summarizes the current status and progress of multi-omics research on CRLM and discusses the application of multi-omics technologies in basic research and the significant clinical implications. |
| format | Article |
| id | doaj-art-623287bcc4284d849bcc14aeb8b1631c |
| institution | Matheson Library |
| issn | 2095-3941 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj-art-623287bcc4284d849bcc14aeb8b1631c2025-07-09T11:21:18ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412025-06-0122661863810.20892/j.issn.2095-3941.2025.0066Multi-omics in colorectal cancer liver metastasis: applications and research advancesKexue Zhou0Chengxiang Yang1Yan Li2School of Medicine Chongqing University, Chongqing 400030, ChinaSchool of Medicine Chongqing University, Chongqing 400030, ChinaSchool of Medicine Chongqing University, Chongqing 400030, ChinaColorectal cancer (CRC) is a common malignant tumor with a high mortality rate worldwide. Advanced CRC often leads to liver metastasis, which has a poor prognosis, highlighting the need to investigate the underlying mechanisms. Omics, encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics, enables comprehensive molecular analysis of cells and tissues. Tumor-omics research has advanced rapidly, with growing attention on CRC-related omics. However, systematic reviews on omics research specific to colorectal cancer liver metastasis (CRLM) are limited. This review summarizes the current status and progress of multi-omics research on CRLM and discusses the application of multi-omics technologies in basic research and the significant clinical implications.https://www.cancerbiomed.org/content/22/6/618colorectal cancer liver metastasisgenomicstranscriptomicsepigenomicsproteomicsmetabolomicsmicrobiomics |
| spellingShingle | Kexue Zhou Chengxiang Yang Yan Li Multi-omics in colorectal cancer liver metastasis: applications and research advances Cancer Biology & Medicine colorectal cancer liver metastasis genomics transcriptomics epigenomics proteomics metabolomics microbiomics |
| title | Multi-omics in colorectal cancer liver metastasis: applications and research advances |
| title_full | Multi-omics in colorectal cancer liver metastasis: applications and research advances |
| title_fullStr | Multi-omics in colorectal cancer liver metastasis: applications and research advances |
| title_full_unstemmed | Multi-omics in colorectal cancer liver metastasis: applications and research advances |
| title_short | Multi-omics in colorectal cancer liver metastasis: applications and research advances |
| title_sort | multi omics in colorectal cancer liver metastasis applications and research advances |
| topic | colorectal cancer liver metastasis genomics transcriptomics epigenomics proteomics metabolomics microbiomics |
| url | https://www.cancerbiomed.org/content/22/6/618 |
| work_keys_str_mv | AT kexuezhou multiomicsincolorectalcancerlivermetastasisapplicationsandresearchadvances AT chengxiangyang multiomicsincolorectalcancerlivermetastasisapplicationsandresearchadvances AT yanli multiomicsincolorectalcancerlivermetastasisapplicationsandresearchadvances |