Microglia-specific NF-κB signaling is a critical regulator of prion-induced glial inflammation and neuronal loss.

Microglia-specific NF-κB signaling is a critical regulator of prion-induced glial inflammation and neuronal loss.

Prion diseases are a group of rare and fatal neurodegenerative diseases caused by the cellular prion protein, PrPC, misfolding into the infectious form, PrPSc, which forms aggregates in the brain. This leads to activation of glial cells, neuroinflammation, and irreversible neuronal loss, however, th...

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Bibliographic Details
Main Authors: Arielle J D Hay, Katriana A Popichak, Genova Mumford, Jifeng Bian, Payton Shirley, Lauren Wolfrath, Michael Eggers, Eric M Nicholson, Ronald B Tjalkens, Mark D Zabel, Julie A Moreno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012582
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