Chronic Obstructive Pulmonary Disease in People with HIV: an Evidence-Based Review
Andrew T Read,1 Jane Akodu,2 Tristan J Barber,2,3 James P Brown,1 Fiona M Burns,2,3 John R Hurst,1,4 Robert F Miller,2,3 Marc CI Lipman1,2,4 1Respiratory Medicine, Royal Free London NHS Foundation Trust, London, UK; 2Ian Charleson Day Centre, Royal Free London NHS Foundation Trust, London, UK; 3Inst...
保存先:
| 主要な著者: | , , , , , , , |
|---|---|
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Dove Medical Press
2025-06-01
|
| シリーズ: | HIV/AIDS: Research and Palliative Care |
| 主題: | |
| オンライン･アクセス: | https://www.dovepress.com/chronic-obstructive-pulmonary-disease-in-people-with-hiv-an-evidence-b-peer-reviewed-fulltext-article-HIV |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|
| 要約: | Andrew T Read,1 Jane Akodu,2 Tristan J Barber,2,3 James P Brown,1 Fiona M Burns,2,3 John R Hurst,1,4 Robert F Miller,2,3 Marc CI Lipman1,2,4 1Respiratory Medicine, Royal Free London NHS Foundation Trust, London, UK; 2Ian Charleson Day Centre, Royal Free London NHS Foundation Trust, London, UK; 3Institute for Global Health, University College London, London, UK; 4UCL Respiratory, University College London, London, UKCorrespondence: Andrew T Read, Royal Free Hospital, Pond Street, London, NW3 2QG, UK, Email Andrew.read5@nhs.netAbstract: HIV co-infection is a risk factor for the development of COPD. HIV enhances the deleterious effects of exposures such as tobacco smoking, as well as interacting with other drivers of COPD such as pulmonary tuberculosis, air pollution and biomass fuel burning. Recent work demonstrates that HIV also contributes independently to COPD pathogenesis by promoting oxidative stress, chronic inflammation, abnormal innate and adaptive immune responses, microbial dysbiosis, and epigenetic alterations within the lung. Consequently, people with HIV develop COPD younger, more often, and with faster rates of lung function decline compared to seronegative individuals. They may also have distinct patterns of lung function abnormalities compared to other etiotypes of COPD. Understanding the natural and pathogenetic history of HIV-associated COPD is important as its assessment, prevention and treatment are currently extrapolated from the general population. Whilst smoking cessation remains vital, further understanding may help guide unique management strategies for HIV-associated COPD. In this review, we explore its epidemiology and pathophysiology and discuss prevention and treatment approaches in this increasingly common disease.Keywords: smoking, emphysema, lung function, airflow obstruction, air pollution, antiretroviral therapy |
|---|---|
| ISSN: | 1179-1373 |