<i>TRIB1</i> and <i>TRPS1</i> Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid Concentrations
In recent years, data from genome-wide association studies (GWAS) have shown that the genes coding for transcriptional repressor GATA binding 1 (<i>TRPS1</i>) and tribbles pseudokinase 1 (<i>TRIB1</i>) play an important role in plasma lipid profiles and act as risk factors fo...
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MDPI AG
2025-05-01
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| author | Gilberto Vargas-Alarcón Óscar Pérez-Méndez Rosalinda Posadas-Sánchez Héctor González-Pacheco Teresa Juárez-Cedillo Galileo Escobedo Victoria López-Olmos José Manuel Fragoso |
| author_facet | Gilberto Vargas-Alarcón Óscar Pérez-Méndez Rosalinda Posadas-Sánchez Héctor González-Pacheco Teresa Juárez-Cedillo Galileo Escobedo Victoria López-Olmos José Manuel Fragoso |
| author_sort | Gilberto Vargas-Alarcón |
| collection | DOAJ |
| description | In recent years, data from genome-wide association studies (GWAS) have shown that the genes coding for transcriptional repressor GATA binding 1 (<i>TRPS1</i>) and tribbles pseudokinase 1 (<i>TRIB1</i>) play an important role in plasma lipid profiles and act as risk factors for coronary heart disease (CHD). The aim of this work was to explore whether single nucleotide polymorphisms (SNPs) in the <i>TRSP1</i> (rs231150 and rs2737229) and <i>TRIB1</i> (rs2980880 and rs2954029) genes are involved in acute coronary syndrome (ACS) and plasma lipid levels. We included 1262 patients diagnosed with ACS and 1051 controls. According to inheritance models, the minor alleles of the SNPs (rs2737229 <i>A</i>, rs2980880 <i>C</i>, and rs2954029 <i>T</i>) were associated with an increased incidence of ACS (<i>p</i> < 0.05). In a sub-analysis that included only the control subjects, the same minor allele frequency was associated with increased total cholesterol, HDL-cholesterol, and LDL-cholesterol levels and low triglyceride levels. In conclusion, rs2737229, rs2980880, and rs2954029 polymorphisms are associated with a risk of developing ACS and with elevated plasma lipid levels. Our results suggest that the <i>TRSP1</i> and <i>TRIB1</i> are implicated in the incidence of ACS through of increased of plasma lipid profile. |
| format | Article |
| id | doaj-art-6145b9c7ed8c4cdc9baafbba0e5e3d6f |
| institution | Matheson Library |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Biology |
| spelling | doaj-art-6145b9c7ed8c4cdc9baafbba0e5e3d6f2025-06-25T13:30:20ZengMDPI AGBiology2079-77372025-05-0114660610.3390/biology14060606<i>TRIB1</i> and <i>TRPS1</i> Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid ConcentrationsGilberto Vargas-Alarcón0Óscar Pérez-Méndez1Rosalinda Posadas-Sánchez2Héctor González-Pacheco3Teresa Juárez-Cedillo4Galileo Escobedo5Victoria López-Olmos6José Manuel Fragoso7Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Tlalpan, Mexico City 14080, MexicoDepartamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Tlalpan, Mexico City 14080, MexicoDepartamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoUnidad Coronaria, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoUnidad de Investigación en Epidemiologia y Servicios de Salud-Área de Envejecimiento, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoDirección de Investigación y Laboratorio de Inmunometabolismo, Hospital General de Mexico, Dr. Eduardo Liceaga, Mexico City 06720, MexicoDepartamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Tlalpan, Mexico City 14080, MexicoDepartamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Tlalpan, Mexico City 14080, MexicoIn recent years, data from genome-wide association studies (GWAS) have shown that the genes coding for transcriptional repressor GATA binding 1 (<i>TRPS1</i>) and tribbles pseudokinase 1 (<i>TRIB1</i>) play an important role in plasma lipid profiles and act as risk factors for coronary heart disease (CHD). The aim of this work was to explore whether single nucleotide polymorphisms (SNPs) in the <i>TRSP1</i> (rs231150 and rs2737229) and <i>TRIB1</i> (rs2980880 and rs2954029) genes are involved in acute coronary syndrome (ACS) and plasma lipid levels. We included 1262 patients diagnosed with ACS and 1051 controls. According to inheritance models, the minor alleles of the SNPs (rs2737229 <i>A</i>, rs2980880 <i>C</i>, and rs2954029 <i>T</i>) were associated with an increased incidence of ACS (<i>p</i> < 0.05). In a sub-analysis that included only the control subjects, the same minor allele frequency was associated with increased total cholesterol, HDL-cholesterol, and LDL-cholesterol levels and low triglyceride levels. In conclusion, rs2737229, rs2980880, and rs2954029 polymorphisms are associated with a risk of developing ACS and with elevated plasma lipid levels. Our results suggest that the <i>TRSP1</i> and <i>TRIB1</i> are implicated in the incidence of ACS through of increased of plasma lipid profile.https://www.mdpi.com/2079-7737/14/6/606susceptibilityacute coronary syndrometranscriptional repressor GATA binding 1tribbles pseudokinase 1 |
| spellingShingle | Gilberto Vargas-Alarcón Óscar Pérez-Méndez Rosalinda Posadas-Sánchez Héctor González-Pacheco Teresa Juárez-Cedillo Galileo Escobedo Victoria López-Olmos José Manuel Fragoso <i>TRIB1</i> and <i>TRPS1</i> Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid Concentrations Biology susceptibility acute coronary syndrome transcriptional repressor GATA binding 1 tribbles pseudokinase 1 |
| title | <i>TRIB1</i> and <i>TRPS1</i> Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid Concentrations |
| title_full | <i>TRIB1</i> and <i>TRPS1</i> Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid Concentrations |
| title_fullStr | <i>TRIB1</i> and <i>TRPS1</i> Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid Concentrations |
| title_full_unstemmed | <i>TRIB1</i> and <i>TRPS1</i> Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid Concentrations |
| title_short | <i>TRIB1</i> and <i>TRPS1</i> Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid Concentrations |
| title_sort | i trib1 i and i trps1 i gene polymorphisms are associated with the incidence of acute coronary syndrome and plasma lipid concentrations |
| topic | susceptibility acute coronary syndrome transcriptional repressor GATA binding 1 tribbles pseudokinase 1 |
| url | https://www.mdpi.com/2079-7737/14/6/606 |
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