Engineered small extracellular vesicles for targeted delivery of perlecan to stabilise the blood–spinal cord barrier after spinal cord injury

Engineered small extracellular vesicles for targeted delivery of perlecan to stabilise the blood–spinal cord barrier after spinal cord injury

Abstract Background Destruction of the blood–spinal cord barrier (BSCB) following spinal cord injury (SCI) can result in various harmful cytokines, neutrophils, and macrophages infiltrating into the injured site, causing secondary damage. Growing evidence shows that M2 macrophages and their small ex...

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Bibliographic Details
Main Authors: Wei Peng, Wentao Zhang, Wei Cui, Wenjin Chen, Yin Zhuang, Rupeng Chu, Jinghua Tan, Jingbo Xue, Yiguo Yan, Guoyong Yin, Shujun Zhang, Yong Xie
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Clinical and Translational Medicine
Subjects:
Blood‒spinal cord barrier repair
M2 macrophage
Perlecan
RGD peptide
Small extracellular vesicles
Spinal cord injury
Online Access:https://doi.org/10.1002/ctm2.70381
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