Effect of Combination Therapy of Oral Famotidine with Mosapride on Intragastric pH and Gastric Emptying in Rats
Background/Aims Studies in healthy humans have reported that the addition of mosapride to acid suppressants resulted in higher intragastric pH than acid suppressant administration alone. We investigated the effect of the addition of mosapride to famotidine on the intragastric pH and gastric emptying...
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Korean College of Helicobacter and Upper Gastrointestinal Research
2021-09-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
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| Online Access: | http://www.helicojournal.org/upload/pdf/kjhugr-2021-0013.pdf |
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| author | Hyun Seok Choi Eui Joong Kim Min Seob Kim Ji Yeon Myung Myeong Hwan Yu Yong Sung Kim Moon Young Lee |
| author_facet | Hyun Seok Choi Eui Joong Kim Min Seob Kim Ji Yeon Myung Myeong Hwan Yu Yong Sung Kim Moon Young Lee |
| author_sort | Hyun Seok Choi |
| collection | DOAJ |
| description | Background/Aims Studies in healthy humans have reported that the addition of mosapride to acid suppressants resulted in higher intragastric pH than acid suppressant administration alone. We investigated the effect of the addition of mosapride to famotidine on the intragastric pH and gastric emptying rate (GER) in rats. Materials and Methods Sixty male Wistar rats were used in this study. Experimental groups were divided into control, famotidine-only, mosapride-only, and famotidine with mosapride (combination). The first experiment was performed in non-stressed rats. Mosapride was administered by oral gavage 1 hour before the meal, and famotidine was administered just before the meal. The rats were provided with food for 30 minutes. The intragastric pH was measured under isoflurane anesthesia, and the GER was measured after harvesting the stomach. In the stress experiment, rats were exposed to 1-hour restraint stress immediately after mosapride administration and subjected to the same process as in the experiment with the non-stressed rats. Results The famotidine-only and combination groups showed significantly higher gastric pH levels than the control group in non-stressed (P<0.01 and P<0.001, respectively) and stressed (P<0.001 and P<0.001, respectively) rats. The combination group also showed significantly higher intragastric pH levels than the famotidine-only group in non-stressed (P<0.01) and stressed (P<0.05) rats. Additionally, combination groups showed a significantly higher GER than the famotidine-only group in non-stressed (P<0.001) and stressed (P<0.01) rats. Conclusions The combination of mosapride with famotidine significantly increased intragastric pH compared to famotidine alone in the non-stressed and stressed rats. |
| format | Article |
| id | doaj-art-60e21ce07fa44a66aaddb8a2b8f39fc6 |
| institution | Matheson Library |
| issn | 1738-3331 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-60e21ce07fa44a66aaddb8a2b8f39fc62025-08-02T09:18:44ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312021-09-0121322022510.7704/kjhugr.2021.0013684Effect of Combination Therapy of Oral Famotidine with Mosapride on Intragastric pH and Gastric Emptying in RatsHyun Seok Choi0Eui Joong Kim1Min Seob Kim2Ji Yeon Myung3Myeong Hwan Yu4Yong Sung Kim5Moon Young Lee6Department of Physiology, Wonkwang University School of Medicine, Iksan, KoreaDepartment of Physiology, Wonkwang University School of Medicine, Iksan, KoreaDepartment of Physiology, Wonkwang University School of Medicine, Iksan, KoreaDepartment of Physiology, Wonkwang University School of Medicine, Iksan, KoreaDepartment of Physiology, Wonkwang University School of Medicine, Iksan, KoreaDepartment of Physiology, Wonkwang University School of Medicine, Iksan, KoreaDepartment of Physiology, Wonkwang University School of Medicine, Iksan, KoreaBackground/Aims Studies in healthy humans have reported that the addition of mosapride to acid suppressants resulted in higher intragastric pH than acid suppressant administration alone. We investigated the effect of the addition of mosapride to famotidine on the intragastric pH and gastric emptying rate (GER) in rats. Materials and Methods Sixty male Wistar rats were used in this study. Experimental groups were divided into control, famotidine-only, mosapride-only, and famotidine with mosapride (combination). The first experiment was performed in non-stressed rats. Mosapride was administered by oral gavage 1 hour before the meal, and famotidine was administered just before the meal. The rats were provided with food for 30 minutes. The intragastric pH was measured under isoflurane anesthesia, and the GER was measured after harvesting the stomach. In the stress experiment, rats were exposed to 1-hour restraint stress immediately after mosapride administration and subjected to the same process as in the experiment with the non-stressed rats. Results The famotidine-only and combination groups showed significantly higher gastric pH levels than the control group in non-stressed (P<0.01 and P<0.001, respectively) and stressed (P<0.001 and P<0.001, respectively) rats. The combination group also showed significantly higher intragastric pH levels than the famotidine-only group in non-stressed (P<0.01) and stressed (P<0.05) rats. Additionally, combination groups showed a significantly higher GER than the famotidine-only group in non-stressed (P<0.001) and stressed (P<0.01) rats. Conclusions The combination of mosapride with famotidine significantly increased intragastric pH compared to famotidine alone in the non-stressed and stressed rats.http://www.helicojournal.org/upload/pdf/kjhugr-2021-0013.pdffamotidinegastric acidgastric emptyingmosapridestresspsychological |
| spellingShingle | Hyun Seok Choi Eui Joong Kim Min Seob Kim Ji Yeon Myung Myeong Hwan Yu Yong Sung Kim Moon Young Lee Effect of Combination Therapy of Oral Famotidine with Mosapride on Intragastric pH and Gastric Emptying in Rats The Korean Journal of Helicobacter and Upper Gastrointestinal Research famotidine gastric acid gastric emptying mosapride stress psychological |
| title | Effect of Combination Therapy of Oral Famotidine with Mosapride on Intragastric pH and Gastric Emptying in Rats |
| title_full | Effect of Combination Therapy of Oral Famotidine with Mosapride on Intragastric pH and Gastric Emptying in Rats |
| title_fullStr | Effect of Combination Therapy of Oral Famotidine with Mosapride on Intragastric pH and Gastric Emptying in Rats |
| title_full_unstemmed | Effect of Combination Therapy of Oral Famotidine with Mosapride on Intragastric pH and Gastric Emptying in Rats |
| title_short | Effect of Combination Therapy of Oral Famotidine with Mosapride on Intragastric pH and Gastric Emptying in Rats |
| title_sort | effect of combination therapy of oral famotidine with mosapride on intragastric ph and gastric emptying in rats |
| topic | famotidine gastric acid gastric emptying mosapride stress psychological |
| url | http://www.helicojournal.org/upload/pdf/kjhugr-2021-0013.pdf |
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