Current Practices on Prescribing and Deprescribing for Patients on Long-Term Antibiotic Treatment for Chronic Pulmonary Conditions: An Umbrella Review by the European Society of Clinical Pharmacy (ESCP)
Purpose Chronic pulmonary conditions require complex treatment strategies involving long-term antibiotic treatment, which carries the highest risk of antimicrobial resistance and adverse drug events (ADE). Specific guidance on prescribing and deprescribing can help reduce these risks and improve the...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | COPD |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15412555.2025.2532076 |
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| author | Ivana Tadic Daniela Fialová Ankie Hazen Martin C. Henman Betul Okuyan Francesca Wirth Abdikarim Abdi Silvana Urru Kayla R. Stover Anita E. Weidmann |
| author_facet | Ivana Tadic Daniela Fialová Ankie Hazen Martin C. Henman Betul Okuyan Francesca Wirth Abdikarim Abdi Silvana Urru Kayla R. Stover Anita E. Weidmann |
| author_sort | Ivana Tadic |
| collection | DOAJ |
| description | Purpose Chronic pulmonary conditions require complex treatment strategies involving long-term antibiotic treatment, which carries the highest risk of antimicrobial resistance and adverse drug events (ADE). Specific guidance on prescribing and deprescribing can help reduce these risks and improve therapy effectiveness. The aim of the study was to determine prescribing and deprescribing practices for long-term antibiotic treatment (≥30 days) in preventing exacerbations of stable chronic pulmonary conditions in adult patients across all healthcare settings.Patients and methods This umbrella review was part of a larger registered study (PROSPERO, CRD42022381268) including systematic reviews and meta-analyses retrieved from PubMed, Cochrane Library, and PsycInfo. Outcomes of interest included condition, antibiotic, dose, duration, (de-) prescribing advice. Standardized methodological tools were used to assess methodological quality of the selected publications (ROBIS), facilitate data extraction (EPOC), and guide narrative summary of findings (PRIOR).Results In total, n = 14 publications were analyzed. (De-)prescribing advice is summarized for treatment (≥30 days) of chronic obstructive pulmonary disease, asthma, non-cystic fibrosis bronchiectasis, cystic fibrosis, and bronchiolitis obliterans syndrome. Macrolides are the most commonly recommended antibiotic for stable chronic pulmonary conditions. ADEs are the main reason for antibiotic discontinuation. Little consideration is given to emergence of antibiotic resistance.Conclusion There is a significant paucity of literature providing specific (de-)prescribing advice for clinical practice. More precise recommendations are required in view of patient safety. |
| format | Article |
| id | doaj-art-60d51a1c63d24d4393cc8f48765c58af |
| institution | Matheson Library |
| issn | 1541-2555 1541-2563 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | COPD |
| spelling | doaj-art-60d51a1c63d24d4393cc8f48765c58af2025-07-28T12:50:28ZengTaylor & Francis GroupCOPD1541-25551541-25632025-12-0122110.1080/15412555.2025.2532076Current Practices on Prescribing and Deprescribing for Patients on Long-Term Antibiotic Treatment for Chronic Pulmonary Conditions: An Umbrella Review by the European Society of Clinical Pharmacy (ESCP)Ivana Tadic0Daniela Fialová1Ankie Hazen2Martin C. Henman3Betul Okuyan4Francesca Wirth5Abdikarim Abdi6Silvana Urru7Kayla R. Stover8Anita E. Weidmann9Department of Clinical Pharmacy, Innsbruck University, Innsbruck, AustriaDepartment of Geriatrics and Gerontology, 1st Faculty of Medicine, Charles University, Prague, Czech RepublicJulius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, NetherlandsTrinity College Dublin, Dublin, IrelandDepartment of Clinical Pharmacy, Faculty of Pharmacy, Marmara University, Istanbul, TurkeyDepartment of Pharmacy, University of Malta, Msida, MaltaDepartment of Clinical Pharmacy, Yeditepe University, Istanbul, TurkeyHospital Pharmacy Uni, S. Chiara General Hospital, APSS, Trento, ItalyDepartment of Pharmacy Practice, School of Pharmacy, University of Mississippi, Jackson, Mississippi, USADepartment of Clinical Pharmacy, Innsbruck University, Innsbruck, AustriaPurpose Chronic pulmonary conditions require complex treatment strategies involving long-term antibiotic treatment, which carries the highest risk of antimicrobial resistance and adverse drug events (ADE). Specific guidance on prescribing and deprescribing can help reduce these risks and improve therapy effectiveness. The aim of the study was to determine prescribing and deprescribing practices for long-term antibiotic treatment (≥30 days) in preventing exacerbations of stable chronic pulmonary conditions in adult patients across all healthcare settings.Patients and methods This umbrella review was part of a larger registered study (PROSPERO, CRD42022381268) including systematic reviews and meta-analyses retrieved from PubMed, Cochrane Library, and PsycInfo. Outcomes of interest included condition, antibiotic, dose, duration, (de-) prescribing advice. Standardized methodological tools were used to assess methodological quality of the selected publications (ROBIS), facilitate data extraction (EPOC), and guide narrative summary of findings (PRIOR).Results In total, n = 14 publications were analyzed. (De-)prescribing advice is summarized for treatment (≥30 days) of chronic obstructive pulmonary disease, asthma, non-cystic fibrosis bronchiectasis, cystic fibrosis, and bronchiolitis obliterans syndrome. Macrolides are the most commonly recommended antibiotic for stable chronic pulmonary conditions. ADEs are the main reason for antibiotic discontinuation. Little consideration is given to emergence of antibiotic resistance.Conclusion There is a significant paucity of literature providing specific (de-)prescribing advice for clinical practice. More precise recommendations are required in view of patient safety.https://www.tandfonline.com/doi/10.1080/15412555.2025.2532076Chronic obstructive pulmonary diseaseasthmanon-cystic fibrosis bronchiectasisbronchiolitis obliterans syndromeantibioticslung diseases |
| spellingShingle | Ivana Tadic Daniela Fialová Ankie Hazen Martin C. Henman Betul Okuyan Francesca Wirth Abdikarim Abdi Silvana Urru Kayla R. Stover Anita E. Weidmann Current Practices on Prescribing and Deprescribing for Patients on Long-Term Antibiotic Treatment for Chronic Pulmonary Conditions: An Umbrella Review by the European Society of Clinical Pharmacy (ESCP) COPD Chronic obstructive pulmonary disease asthma non-cystic fibrosis bronchiectasis bronchiolitis obliterans syndrome antibiotics lung diseases |
| title | Current Practices on Prescribing and Deprescribing for Patients on Long-Term Antibiotic Treatment for Chronic Pulmonary Conditions: An Umbrella Review by the European Society of Clinical Pharmacy (ESCP) |
| title_full | Current Practices on Prescribing and Deprescribing for Patients on Long-Term Antibiotic Treatment for Chronic Pulmonary Conditions: An Umbrella Review by the European Society of Clinical Pharmacy (ESCP) |
| title_fullStr | Current Practices on Prescribing and Deprescribing for Patients on Long-Term Antibiotic Treatment for Chronic Pulmonary Conditions: An Umbrella Review by the European Society of Clinical Pharmacy (ESCP) |
| title_full_unstemmed | Current Practices on Prescribing and Deprescribing for Patients on Long-Term Antibiotic Treatment for Chronic Pulmonary Conditions: An Umbrella Review by the European Society of Clinical Pharmacy (ESCP) |
| title_short | Current Practices on Prescribing and Deprescribing for Patients on Long-Term Antibiotic Treatment for Chronic Pulmonary Conditions: An Umbrella Review by the European Society of Clinical Pharmacy (ESCP) |
| title_sort | current practices on prescribing and deprescribing for patients on long term antibiotic treatment for chronic pulmonary conditions an umbrella review by the european society of clinical pharmacy escp |
| topic | Chronic obstructive pulmonary disease asthma non-cystic fibrosis bronchiectasis bronchiolitis obliterans syndrome antibiotics lung diseases |
| url | https://www.tandfonline.com/doi/10.1080/15412555.2025.2532076 |
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