Association between body mass index and long-term all-cause mortality in critically ill patients without malignant tumors.
<h4>Background</h4>The "obesity paradox" in certain diseases has been reported in previous studies. This study aimed to investigate the relationship between BMI and long-term mortality in all critically ill patients without malignant tumors who were admitted to the ICU.<h4&g...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0325452 |
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| Summary: | <h4>Background</h4>The "obesity paradox" in certain diseases has been reported in previous studies. This study aimed to investigate the relationship between BMI and long-term mortality in all critically ill patients without malignant tumors who were admitted to the ICU.<h4>Methods</h4>Using the MIMIC-IV 2.2 database, we included all ICU admissions for patients without malignant tumors and categorized them into four groups based on the World Health Organization (WHO) obesity criteria. The relationship between BMI and 90-day, 180-day, and 1-year mortality was analyzed using univariate and multivariate Cox regression models, along with restricted cubic spline (RCS) models to account for potential non-linear associations.<h4>Results</h4>A total of 19,089 patients were included, with 90-day, 180-day, and 1-year mortality rates of 18.35%, 20.80%, and 23.96%, respectively. Overweight and obese patients exhibited significantly lower mortality rates compared to underweight and normal-weight individuals at all time points. After adjusting for confounders, higher BMI remained a protective factor for long-term mortality (HR 0.65-0.72, P < 0.001). RCS curves demonstrated a U-shaped relationship between BMI and mortality, and subgroup analyses confirmed the protective effect of higher BMI in different subgroups.<h4>Conclusion</h4>The "obesity paradox" may apply to critically ill patients without malignant tumors. |
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| ISSN: | 1932-6203 |