Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis

Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis

<b>Background/Objectives</b>: Prenatal adverse events may influence the development of complications of prematurity, including patent ductus arteriosus (PDA). We conducted a systematic review and Bayesian model-averaged (BMA) meta-analysis of observational studies exploring the associati...

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Bibliographic Details
Main Authors: Moreyba Borges-Luján, Gloria Galán-Henríquez, Rosa I. Rodríguez-Viera, František Bartoš, Gema E. González-Luis, Eduardo Villamor
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Children
Subjects:
patent ductus arteriosus
preeclampsia
preterm infant
Bayesian statistics
meta-analysis
Online Access:https://www.mdpi.com/2227-9067/12/6/762
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Summary:<b>Background/Objectives</b>: Prenatal adverse events may influence the development of complications of prematurity, including patent ductus arteriosus (PDA). We conducted a systematic review and Bayesian model-averaged (BMA) meta-analysis of observational studies exploring the association between hypertensive disorders of pregnancy (HDP) and the risk of PDA in preterm infants. <b>Methods</b>: PubMed/Medline and Embase databases were searched. We used BMA analysis to calculate Bayes factors (BFs). The BF<sub>10</sub> is the ratio of the probability of the data under the alternative hypothesis (H<sub>1</sub>, presence of association) over the probability of the data under the null hypothesis (H<sub>0</sub>, absence of association). <b>Results</b>: We included 41 studies (58,004 infants). BMA analysis showed moderate evidence in favour of H<sub>0</sub> for the association between HDP and any PDA (BF<sub>10</sub> = 0.20) as well as for the association between HDP and hemodynamically significant PDA (BF<sub>10</sub> = 0.27). Subgroup analyses based on the subtype of HDP showed that the moderate evidence in favour of H<sub>0</sub> was only conclusive (i.e., BF<sub>10</sub> < 0.33) for the associations of any PDA with preeclampsia (BF<sub>10</sub> = 0.30) and hemodynamically significant PDA with preeclampsia (BF<sub>10</sub> = 0.17). <b>Conclusions</b>: The currently available evidence suggests a lack of association between HDP and the risk of developing PDA.
ISSN:2227-9067

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