Bioadhesive and antioxidant hydrogel by MoS2-TA dual-catalytic system initiated free radical polymerization combined with phototherapy for cartilage regeneration
Tissue engineering has been used as a potential treatment strategy for articular cartilage regeneration, but current hydrogel scaffolds often fail to meet these criteria due to weak mechanical strength and unfavorable biocompatibility. Inspired by the metal ion-polyphenol redox system-initiated free...
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Elsevier
2025-08-01
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| author | Qingbing Jiang Yifeng Shang Hong Cheng Jinmin Zhao Lerong Yang Zhenzhen He Jiyong Wei Ruiming Liang Wei Su Li Zheng Chuanan Liao |
| author_facet | Qingbing Jiang Yifeng Shang Hong Cheng Jinmin Zhao Lerong Yang Zhenzhen He Jiyong Wei Ruiming Liang Wei Su Li Zheng Chuanan Liao |
| author_sort | Qingbing Jiang |
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| description | Tissue engineering has been used as a potential treatment strategy for articular cartilage regeneration, but current hydrogel scaffolds often fail to meet these criteria due to weak mechanical strength and unfavorable biocompatibility. Inspired by the metal ion-polyphenol redox system-initiated free radical polymerization (MPi-FRP), a novel molybdenum disulfide-tannic acid (MoS2-TA) dual-catalytic system was used as an initiator for the free radical polymerization of methacrylated hyaluronate (HAMA) to synthesize a HAMA-MoS2-TA (abbreviated as HAMA-M) nanocomposite hydrogel for cartilage repair under mild conditions. Compared to the pure HAMA hydrogel, HAMA-M hydrogels exhibited robust mechanical properties, and the adhesive strength was promoted for 81.32 %. Moreover, MoS2-TA endowed the hydrogel with excellent SOD and CAT-mimic activities and prominent photothermal conversion efficiency. Assisted by the mild photothermal therapy, the antioxidant HAMA-M hydrogel had excellent biocompatibility and effectively promoted chondrogenic differentiation of bone marrow mesenchymal stem cells by decreasing excessive ROS production, restoring mitochondrial function and promoting mitochondrial production. Further, the HAMA-M hydrogel alleviated the pro-inflammatory microenvironment and accelerated cartilage regeneration, with the ICCS score promoted to 77.75 % after 8-week therapy in vivo. This study provides a novel way for fabricating tissue engineering scaffolds and throws new light for cartilage repair. |
| format | Article |
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| institution | Matheson Library |
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| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
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| spelling | doaj-art-5f36700ea49f41df8c05a725cd9f4da62025-07-13T04:54:48ZengElsevierMaterials Today Bio2590-00642025-08-0133102056Bioadhesive and antioxidant hydrogel by MoS2-TA dual-catalytic system initiated free radical polymerization combined with phototherapy for cartilage regenerationQingbing Jiang0Yifeng Shang1Hong Cheng2Jinmin Zhao3Lerong Yang4Zhenzhen He5Jiyong Wei6Ruiming Liang7Wei Su8Li Zheng9Chuanan Liao10Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed By the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, ChinaGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed By the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China; Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong 250014, ChinaGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed By the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, ChinaGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed By the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, ChinaGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed By the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, ChinaGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed By the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, ChinaGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed By the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, ChinaGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed By the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China; Corresponding author. Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, ChinaGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed By the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China; Corresponding author. Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed By the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China; Corresponding author. Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed By the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, 530021, China; Corresponding author. Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues, Guangxi Key Laboratory of Regenerative Medicine, Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.Tissue engineering has been used as a potential treatment strategy for articular cartilage regeneration, but current hydrogel scaffolds often fail to meet these criteria due to weak mechanical strength and unfavorable biocompatibility. Inspired by the metal ion-polyphenol redox system-initiated free radical polymerization (MPi-FRP), a novel molybdenum disulfide-tannic acid (MoS2-TA) dual-catalytic system was used as an initiator for the free radical polymerization of methacrylated hyaluronate (HAMA) to synthesize a HAMA-MoS2-TA (abbreviated as HAMA-M) nanocomposite hydrogel for cartilage repair under mild conditions. Compared to the pure HAMA hydrogel, HAMA-M hydrogels exhibited robust mechanical properties, and the adhesive strength was promoted for 81.32 %. Moreover, MoS2-TA endowed the hydrogel with excellent SOD and CAT-mimic activities and prominent photothermal conversion efficiency. Assisted by the mild photothermal therapy, the antioxidant HAMA-M hydrogel had excellent biocompatibility and effectively promoted chondrogenic differentiation of bone marrow mesenchymal stem cells by decreasing excessive ROS production, restoring mitochondrial function and promoting mitochondrial production. Further, the HAMA-M hydrogel alleviated the pro-inflammatory microenvironment and accelerated cartilage regeneration, with the ICCS score promoted to 77.75 % after 8-week therapy in vivo. This study provides a novel way for fabricating tissue engineering scaffolds and throws new light for cartilage repair.http://www.sciencedirect.com/science/article/pii/S259000642500626XCartilage regenerationMolybdenum disulfide-tannic acid (MoS2-TA) dual-catalytic systemPhotothermal therapyCartilage tissue engineering |
| spellingShingle | Qingbing Jiang Yifeng Shang Hong Cheng Jinmin Zhao Lerong Yang Zhenzhen He Jiyong Wei Ruiming Liang Wei Su Li Zheng Chuanan Liao Bioadhesive and antioxidant hydrogel by MoS2-TA dual-catalytic system initiated free radical polymerization combined with phototherapy for cartilage regeneration Materials Today Bio Cartilage regeneration Molybdenum disulfide-tannic acid (MoS2-TA) dual-catalytic system Photothermal therapy Cartilage tissue engineering |
| title | Bioadhesive and antioxidant hydrogel by MoS2-TA dual-catalytic system initiated free radical polymerization combined with phototherapy for cartilage regeneration |
| title_full | Bioadhesive and antioxidant hydrogel by MoS2-TA dual-catalytic system initiated free radical polymerization combined with phototherapy for cartilage regeneration |
| title_fullStr | Bioadhesive and antioxidant hydrogel by MoS2-TA dual-catalytic system initiated free radical polymerization combined with phototherapy for cartilage regeneration |
| title_full_unstemmed | Bioadhesive and antioxidant hydrogel by MoS2-TA dual-catalytic system initiated free radical polymerization combined with phototherapy for cartilage regeneration |
| title_short | Bioadhesive and antioxidant hydrogel by MoS2-TA dual-catalytic system initiated free radical polymerization combined with phototherapy for cartilage regeneration |
| title_sort | bioadhesive and antioxidant hydrogel by mos2 ta dual catalytic system initiated free radical polymerization combined with phototherapy for cartilage regeneration |
| topic | Cartilage regeneration Molybdenum disulfide-tannic acid (MoS2-TA) dual-catalytic system Photothermal therapy Cartilage tissue engineering |
| url | http://www.sciencedirect.com/science/article/pii/S259000642500626X |
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