RACK7 senses and fine-tunes enhancer activity

RACK7 senses and fine-tunes enhancer activity

Summary: Enhancers regulate dynamic gene expression in a spatiotemporal specific manner. A number of positive as well as negative regulators of enhancers have been reported so far. However, whether and how these regulators sense enhancer activity dynamics remains unclear. In this study, we show that...

Full description

Saved in:
Bibliographic Details
Main Authors: Li Dong, Daixuan Zhang, Ying Cai, Min Zeng, Mandi Mu, Peng Zhao, Jin Wang, Siyi Cheng, Qingqing Cai, Jian Zhang, Yajun Hu, Lei Zhang, Li Tan, Feizhen Wu, Yujiang Geno Shi, Wenqi Xu, Hongjie Shen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Biochemistry
Molecular mechanism of gene regulation
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225013446
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary: Enhancers regulate dynamic gene expression in a spatiotemporal specific manner. A number of positive as well as negative regulators of enhancers have been reported so far. However, whether and how these regulators sense enhancer activity dynamics remains unclear. In this study, we show that a specific enhancer regulator, RACK7, swiftly re-distributes from repressed enhancers to activated enhancers in response to a plethora of acute stimulations. We further show that this process depends on transcription and RACK7 positively regulates enhancer activation by promoting the recruitment of RNA polymerase II. Taken together, our findings suggest that RACK7 senses enhancer activity changes and facilitates their activation during acute stimulations.
ISSN:2589-0042

Similar Items