Maternal smoking around birth is associated with an increased risk of offspring constipation: Evidence from a Mendelian randomization study
Introduction This study aimed to investigate the association between maternal smoking around birth and the incidence of offspring constipation. Methods Genome-wide association study (GWAS) data for maternal smoking around birth and offspring constipation were obtained from the Mendelian randomizati...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2025-05-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | https://www.tobaccoinduceddiseases.org/Maternal-smoking-around-birth-is-associated-with-an-increased-risk-of-offspring-constipation,203866,0,2.html |
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| Summary: | Introduction
This study aimed to investigate the association between maternal
smoking around birth and the incidence of offspring constipation.
Methods
Genome-wide association study (GWAS) data for maternal smoking
around birth and offspring constipation were obtained from the Mendelian
randomization (MR) Base platform. Single nucleotide polymorphisms (SNPs)
significantly associated with maternal smoking around birth were utilized as
instrumental variables in two-sample MR analyses to explore the relationship
between maternal smoking and offspring constipation. The analytical methods
employed included the inverse-variance weighted (IVW) method, weighted
median estimator, and MR-Egger regression.
Results
Twenty SNPs significantly associated with maternal smoking around birth
(p<5×10 -8 ; linkage disequilibrium r 2 <0.001) were identified. Across the different
methods, a consistent positive association was observed between maternal smoking
around birth and an increased risk of constipation in offspring (IVW: OR=4.35;
95% CI: 1.81–10.45; weighted median estimator: OR=4.23; 95% CI: 1.22–14.75;
MR-Egger: OR=0.92; 95% CI: 0.01–122.07), suggesting that higher frequency of
maternal smoking is associated with an elevated risk of constipation in offspring.
However, we did not detect any potential effect of genetic liability to constipation
risk on maternal smoking.
Conclusions
This study provides evidence suggesting that increased maternal
smoking around the time of birth may be linked to a higher risk of constipation
in offspring. |
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| ISSN: | 1617-9625 |