Discovery of Novel CRK12 Inhibitors for the Treatment of Human African Trypanosomiasis: An Integrated Computational and Experimental Approach
<b>Background:</b> Human African trypanosomiasis (HAT), caused by <i>Trypanosoma brucei</i>, is a neglected tropical disease with limited treatments, highlighting the pressing need for new drugs. Cell division cycle-2-related kinase 12 (CRK12), a pivotal protein involved in t...
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Main Authors: | Qin Li, Jiayi Luo, Chenggong Fu, Wenqingqing Kang, Lingling Wang, Henry Tong, Zhaorong Lun, Qianqian Zhang, Dehua Lai, Huanxiang Liu |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2025-05-01
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Series: | Pharmaceuticals |
Subjects: | |
Online Access: | https://www.mdpi.com/1424-8247/18/6/778 |
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