Coherence locking in a parallel nuclear magnetic resonance probe defends against gradient field spillover
<p>The implementation of parallel nuclear magnetic resonance detection aims to enhance measurement throughput in support of high-throughput-screening applications, including, for example, drug discovery. In support of modern pulse sequences and solvent suppression methods, each detection site...
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| Language: | English |
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Copernicus Publications
2025-07-01
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| Series: | Magnetic Resonance |
| Online Access: | https://mr.copernicus.org/articles/6/173/2025/mr-6-173-2025.pdf |
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| author | M. He N. MacKinnon D. Buyens B. Luy B. Luy J. G. Korvink |
| author_facet | M. He N. MacKinnon D. Buyens B. Luy B. Luy J. G. Korvink |
| author_sort | M. He |
| collection | DOAJ |
| description | <p>The implementation of parallel nuclear magnetic resonance detection aims to enhance measurement throughput in support of high-throughput-screening applications, including, for example, drug discovery. In support of modern pulse sequences and solvent suppression methods, each detection site must have independent pulsed field gradient capabilities. Hereby, a challenge is introduced in which the local gradients applied in parallel detectors introduce field spillover into adjacent channels, leading to spin dephasing and, hence, to signal suppression. This study proposes a compensation scheme employing optimized pulses to achieve coherence locking during gradient pulse periods. The design of coherence-locking pulses utilizes optimal control to address gradient-induced field inhomogeneity. These pulses are applied in a pulsed-gradient spin echo (PGSE) experiment and a parallel heteronuclear single quantum coherence (HSQC) experiment, demonstrating their effectiveness in protecting the desired coherences from gradient field spillover. This compensation scheme presents a valuable solution for magnetic resonance probes equipped with parallel and independently switchable gradient coils.</p> |
| format | Article |
| id | doaj-art-5ab8fe6e0c4a4e5cb1ecea8cf19d2be6 |
| institution | Matheson Library |
| issn | 2699-0016 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Copernicus Publications |
| record_format | Article |
| series | Magnetic Resonance |
| spelling | doaj-art-5ab8fe6e0c4a4e5cb1ecea8cf19d2be62025-07-17T05:55:43ZengCopernicus PublicationsMagnetic Resonance2699-00162025-07-01617318110.5194/mr-6-173-2025Coherence locking in a parallel nuclear magnetic resonance probe defends against gradient field spilloverM. He0N. MacKinnon1D. Buyens2B. Luy3B. Luy4J. G. Korvink5Institute of Microstructure Technology, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, GermanyInstitute of Microstructure Technology, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, GermanyInstitute of Microstructure Technology, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, GermanyInstitute for Biological Interfaces 4 – Magnetic Resonance, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, GermanyInstitute of Organic Chemistry, Karlsruhe Institute of Technology, Karlsruhe, GermanyInstitute of Microstructure Technology, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany<p>The implementation of parallel nuclear magnetic resonance detection aims to enhance measurement throughput in support of high-throughput-screening applications, including, for example, drug discovery. In support of modern pulse sequences and solvent suppression methods, each detection site must have independent pulsed field gradient capabilities. Hereby, a challenge is introduced in which the local gradients applied in parallel detectors introduce field spillover into adjacent channels, leading to spin dephasing and, hence, to signal suppression. This study proposes a compensation scheme employing optimized pulses to achieve coherence locking during gradient pulse periods. The design of coherence-locking pulses utilizes optimal control to address gradient-induced field inhomogeneity. These pulses are applied in a pulsed-gradient spin echo (PGSE) experiment and a parallel heteronuclear single quantum coherence (HSQC) experiment, demonstrating their effectiveness in protecting the desired coherences from gradient field spillover. This compensation scheme presents a valuable solution for magnetic resonance probes equipped with parallel and independently switchable gradient coils.</p>https://mr.copernicus.org/articles/6/173/2025/mr-6-173-2025.pdf |
| spellingShingle | M. He N. MacKinnon D. Buyens B. Luy B. Luy J. G. Korvink Coherence locking in a parallel nuclear magnetic resonance probe defends against gradient field spillover Magnetic Resonance |
| title | Coherence locking in a parallel nuclear magnetic resonance probe defends against gradient field spillover |
| title_full | Coherence locking in a parallel nuclear magnetic resonance probe defends against gradient field spillover |
| title_fullStr | Coherence locking in a parallel nuclear magnetic resonance probe defends against gradient field spillover |
| title_full_unstemmed | Coherence locking in a parallel nuclear magnetic resonance probe defends against gradient field spillover |
| title_short | Coherence locking in a parallel nuclear magnetic resonance probe defends against gradient field spillover |
| title_sort | coherence locking in a parallel nuclear magnetic resonance probe defends against gradient field spillover |
| url | https://mr.copernicus.org/articles/6/173/2025/mr-6-173-2025.pdf |
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