Coherence locking in a parallel nuclear magnetic resonance probe defends against gradient field spillover
<p>The implementation of parallel nuclear magnetic resonance detection aims to enhance measurement throughput in support of high-throughput-screening applications, including, for example, drug discovery. In support of modern pulse sequences and solvent suppression methods, each detection site...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Copernicus Publications
2025-07-01
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| Series: | Magnetic Resonance |
| Online Access: | https://mr.copernicus.org/articles/6/173/2025/mr-6-173-2025.pdf |
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| Summary: | <p>The implementation of parallel nuclear magnetic resonance detection aims to enhance measurement throughput in support of high-throughput-screening applications, including, for example, drug discovery. In support of modern pulse sequences and solvent suppression methods, each detection site must have independent pulsed field gradient capabilities. Hereby, a challenge is introduced in which the local gradients applied in parallel detectors introduce field spillover into adjacent channels, leading to spin dephasing and, hence, to signal suppression. This study proposes a compensation scheme employing optimized pulses to achieve coherence locking during gradient pulse periods. The design of coherence-locking pulses utilizes optimal control to address gradient-induced field inhomogeneity. These pulses are applied in a pulsed-gradient spin echo (PGSE) experiment and a parallel heteronuclear single quantum coherence (HSQC) experiment, demonstrating their effectiveness in protecting the desired coherences from gradient field spillover. This compensation scheme presents a valuable solution for magnetic resonance probes equipped with parallel and independently switchable gradient coils.</p> |
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| ISSN: | 2699-0016 |