The next generation of dental treatments: Leveraging smart-responsive nanomaterials for unique oral environments
Oral diseases are highly prevalent worldwide and are a burden to public health systems and economic resources. They often destroy oral tissues, impairing essential functions such as mastication and speech. Conventional therapeutic strategies face several challenges, including poor biocompatibility a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425006271 |
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| author | Chenying Cui Jingyu Yan Lihong Zhou Yurong Xu Guning Wang Xiuping Wu Bing Li |
| author_facet | Chenying Cui Jingyu Yan Lihong Zhou Yurong Xu Guning Wang Xiuping Wu Bing Li |
| author_sort | Chenying Cui |
| collection | DOAJ |
| description | Oral diseases are highly prevalent worldwide and are a burden to public health systems and economic resources. They often destroy oral tissues, impairing essential functions such as mastication and speech. Conventional therapeutic strategies face several challenges, including poor biocompatibility and limited regenerative outcomes, and are frequently constrained by the complex and dynamic oral microenvironment. Smart-responsive nanomaterials provide effective solutions by dynamically reacting to key pathological features of the oral milieu, such as dysbiosis, oxidative stress, acidic pH, and immune imbalance. These materials facilitate targeted tissue repair and regeneration through the precise, stimuli-responsive release of therapeutic agents. In this review, we summarized the unique physiological and pathological characteristics of the oral microenvironment, discussed the fundamental response mechanisms of nanomaterials sensitive to physical, chemical, and biological stimuli, and analyzed the composition and design of emerging nanoplatforms. We highlighted their applications in tooth and periodontal tissue regeneration and discussed current challenges and key considerations in clinical translation to provide a theoretical foundation for future clinical advancements in oral regenerative medicine. |
| format | Article |
| id | doaj-art-5a787ff7b4b64cdbb2e55d76b3d4261e |
| institution | Matheson Library |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-5a787ff7b4b64cdbb2e55d76b3d4261e2025-07-11T04:31:35ZengElsevierMaterials Today Bio2590-00642025-08-0133102057The next generation of dental treatments: Leveraging smart-responsive nanomaterials for unique oral environmentsChenying Cui0Jingyu Yan1Lihong Zhou2Yurong Xu3Guning Wang4Xiuping Wu5Bing Li6Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, Shanxi, ChinaShanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, Shanxi, ChinaShanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, Shanxi, China; Academy of Medical Sciences, Shanxi Medical University, Taiyuan, 030001, Shanxi, ChinaShanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, Shanxi, ChinaShanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, Shanxi, ChinaShanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, Shanxi, China; Corresponding author. Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China.Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, Shanxi, China; Corresponding author. Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China.Oral diseases are highly prevalent worldwide and are a burden to public health systems and economic resources. They often destroy oral tissues, impairing essential functions such as mastication and speech. Conventional therapeutic strategies face several challenges, including poor biocompatibility and limited regenerative outcomes, and are frequently constrained by the complex and dynamic oral microenvironment. Smart-responsive nanomaterials provide effective solutions by dynamically reacting to key pathological features of the oral milieu, such as dysbiosis, oxidative stress, acidic pH, and immune imbalance. These materials facilitate targeted tissue repair and regeneration through the precise, stimuli-responsive release of therapeutic agents. In this review, we summarized the unique physiological and pathological characteristics of the oral microenvironment, discussed the fundamental response mechanisms of nanomaterials sensitive to physical, chemical, and biological stimuli, and analyzed the composition and design of emerging nanoplatforms. We highlighted their applications in tooth and periodontal tissue regeneration and discussed current challenges and key considerations in clinical translation to provide a theoretical foundation for future clinical advancements in oral regenerative medicine.http://www.sciencedirect.com/science/article/pii/S2590006425006271Oral microenvironmentSmart-responsive nanomaterialsTooth tissuePeriodontal tissueTissue regeneration |
| spellingShingle | Chenying Cui Jingyu Yan Lihong Zhou Yurong Xu Guning Wang Xiuping Wu Bing Li The next generation of dental treatments: Leveraging smart-responsive nanomaterials for unique oral environments Materials Today Bio Oral microenvironment Smart-responsive nanomaterials Tooth tissue Periodontal tissue Tissue regeneration |
| title | The next generation of dental treatments: Leveraging smart-responsive nanomaterials for unique oral environments |
| title_full | The next generation of dental treatments: Leveraging smart-responsive nanomaterials for unique oral environments |
| title_fullStr | The next generation of dental treatments: Leveraging smart-responsive nanomaterials for unique oral environments |
| title_full_unstemmed | The next generation of dental treatments: Leveraging smart-responsive nanomaterials for unique oral environments |
| title_short | The next generation of dental treatments: Leveraging smart-responsive nanomaterials for unique oral environments |
| title_sort | next generation of dental treatments leveraging smart responsive nanomaterials for unique oral environments |
| topic | Oral microenvironment Smart-responsive nanomaterials Tooth tissue Periodontal tissue Tissue regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425006271 |
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