Lymphoma B cells remodel bone marrow stromal cells into extracellular matrix–producing cancer-associated fibroblasts

Lymphoma B cells remodel bone marrow stromal cells into extracellular matrix–producing cancer-associated fibroblasts

Abstract: Bone marrow (BM) involvement is a common feature of germinal center–derived B-cell lymphomas and is associated with a poor prognosis. In particular, follicular lymphoma (FL) infiltrates the BM in 70% of cases, and analysis of in vitro–expanded FL BM mesenchymal stromal cells (MSCs) has rev...

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Main Authors: Elise Dessauge, Baptiste Brauge, Simon Léonard, Alicia Beyou, Camille Laurent, Valentin Isen, Nicolas Barbier, Céline Monvoisin, Thomas Lejeune, Jérôme Destin, Florence Jouan, Judikael Saout, Francisco Llamas-Gutierrez, Franck Morschhauser, Sandrine Roulland, David Roulois, Frédéric Mourcin, Karin Tarte
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925002575
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