The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial
<i>Background and Objectives:</i> Preliminary studies indicate that dihydrogen (H<sub>2</sub>) may affect molecular pathways involved in appetite regulation; however, its role in influencing patient-reported appetite outcomes in individuals with obesity remains uncertain. Thi...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/61/7/1299 |
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| Summary: | <i>Background and Objectives:</i> Preliminary studies indicate that dihydrogen (H<sub>2</sub>) may affect molecular pathways involved in appetite regulation; however, its role in influencing patient-reported appetite outcomes in individuals with obesity remains uncertain. This randomized, placebo-controlled, double-blind trial aimed to evaluate the effects of H<sub>2</sub> supplementation on appetite, body composition, sleep quality, obesity-specific quality of life, and related biomarkers in obese men and women. <i>Materials and Methods:</i> The study included 36 participants (24 females; age 42.1 ± 13.2 years; BMI 30.8 ± 4.2 kg/m<sup>2</sup>) randomized to receive either 1.0 L of hydrogen-rich water (15 mg of H<sub>2</sub>) or 1.0 L of control water (0 mg of H<sub>2</sub>) daily for eight weeks. <i>Results:</i> The results demonstrated that hydrogen-rich water significantly mitigated cravings (<i>p</i> = 0.05), improved subjective sleep quality (<i>p</i> = 0.05), reduced total cholesterol (<i>p</i> = 0.02) and LDL cholesterol (<i>p</i> = 0.04), and increased plasma glucagon-like peptide-1 levels (<i>p</i> = 0.05) compared to the control. No severe adverse effects were reported throughout the trial. <i>Conclusions:</i> These findings suggest that hydrogen-rich water may serve as a safe and effective dietary strategy to address appetite regulation and related metabolic indices in individuals with obesity. The study is registered at ClinicalTrials.gov (NCT06722326). |
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| ISSN: | 1010-660X 1648-9144 |