Impact of the Human Microbiome on Nephrolithiasis
Nephrolithiasis has many causes, and its prevalence is increasing worldwide. The interest in the human microbiome is growing because of the advance of new diagnostic techniques, and recent studies have suggested a link between the microbiome and nephrolithiasis. This paper reviewed the role of the m...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Association of Urogenital Tract Infection and Inflammation
2021-08-01
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| Series: | Urogenital Tract Infection |
| Subjects: | |
| Online Access: | http://euti.org/upload/pdf/UTI016-02-25.pdf |
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| Summary: | Nephrolithiasis has many causes, and its prevalence is increasing worldwide. The interest in the human microbiome is growing because of the advance of new diagnostic techniques, and recent studies have suggested a link between the microbiome and nephrolithiasis. This paper reviewed the role of the microbiome in nephrolithiasis. The absence of Oxalobacter formigenes induces hyperoxaluria, which promotes calcium oxalate stone (CaOx) formation. Escherichia coli promote CaOx supersaturation through hypocitraturia caused by the bacterial production of citrate lyase. Infection stones are associated with urea-splitting organisms, particularly Proteus mirabilis, and the stones themselves contain many species of bacteria. |
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| ISSN: | 2465-8243 2465-8510 |