Comparative assessments of myocardial iron load in thalassemia patients between dark blood and bright blood MRI T2* techniques
ObjectiveTo investigate the difference of black blood (DB) and bright blood (BB) T2* techniques at 1.5 T and 3 T in the assessment of myocardial iron load in patients with thalassemia (TM).MethodsAs a retrospective study. CMRtools software was used to measure myocardial T2* in 359 patients with mode...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1608870/full |
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| author | Jixing Yi Min Wu Suzhen Wei Qiliang Huang Bumin Liang Peng Peng Tao Li Fengming Xu |
| author_facet | Jixing Yi Min Wu Suzhen Wei Qiliang Huang Bumin Liang Peng Peng Tao Li Fengming Xu |
| author_sort | Jixing Yi |
| collection | DOAJ |
| description | ObjectiveTo investigate the difference of black blood (DB) and bright blood (BB) T2* techniques at 1.5 T and 3 T in the assessment of myocardial iron load in patients with thalassemia (TM).MethodsAs a retrospective study. CMRtools software was used to measure myocardial T2* in 359 patients with moderate (60 g/L < Hemoglobin<90 g/L) or severe (Hemoglobin<60 g/L) thalassemia. A truncation method was used to remove signal values that deviated from the fitted curve. T2* (DBx-T2*, BBx-T2*) containing all (eight echoes) signals (DB8-T2*, BB8-T2*) and the optimal signal (coefficient of determination R2 > 0.95) were recorded. The difference, correlation and consistency of T2* measured by different methods were compared.ResultsThere was no significant difference (p > 0.05) in myocardial T2* measured by different methods (1.5 T, 3 T), and all of them were highly positively correlated (p < 0.05, rs > 0.9). Bland–Altman analysis showed that (1.5 T) DB8-T2* and DBx-T2*, DBx-T2* and BBx-T2* had good consistency (p > 0.05). (3 T) DB8-T2* and DBx-T2* had good consistency (p > 0.05). There were proportional differences in T2* values measured by the other methods (p < 0.05), and none of them could be considered to have good consistency.ConclusionDB CMR T2* and BB CMR T2* can be interchangeable in the assessment of myocardial iron load in TM patients. However, DB CMR T2* is more stable and reliable. |
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| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-556a38d0183c488f9dd2d2d26ac5837f2025-07-31T05:37:25ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.16088701608870Comparative assessments of myocardial iron load in thalassemia patients between dark blood and bright blood MRI T2* techniquesJixing Yi0Min Wu1Suzhen Wei2Qiliang Huang3Bumin Liang4Peng Peng5Tao Li6Fengming Xu7Department of Radiology, Liuzhou Worker’s Hospital, Liuzhou, ChinaDepartment of Radiology, Liuzhou Worker’s Hospital, Liuzhou, ChinaDepartment of Radiology, Liuzhou Worker’s Hospital, Liuzhou, ChinaDepartment of Gastroenterology, Liuzhou Worker’s Hospital, Liuzhou, ChinaSchool of International Education, Guangxi Medical University, Nanning, ChinaDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiology, Liuzhou Worker’s Hospital, Liuzhou, ChinaDepartment of Radiology, Liuzhou Worker’s Hospital, Liuzhou, ChinaObjectiveTo investigate the difference of black blood (DB) and bright blood (BB) T2* techniques at 1.5 T and 3 T in the assessment of myocardial iron load in patients with thalassemia (TM).MethodsAs a retrospective study. CMRtools software was used to measure myocardial T2* in 359 patients with moderate (60 g/L < Hemoglobin<90 g/L) or severe (Hemoglobin<60 g/L) thalassemia. A truncation method was used to remove signal values that deviated from the fitted curve. T2* (DBx-T2*, BBx-T2*) containing all (eight echoes) signals (DB8-T2*, BB8-T2*) and the optimal signal (coefficient of determination R2 > 0.95) were recorded. The difference, correlation and consistency of T2* measured by different methods were compared.ResultsThere was no significant difference (p > 0.05) in myocardial T2* measured by different methods (1.5 T, 3 T), and all of them were highly positively correlated (p < 0.05, rs > 0.9). Bland–Altman analysis showed that (1.5 T) DB8-T2* and DBx-T2*, DBx-T2* and BBx-T2* had good consistency (p > 0.05). (3 T) DB8-T2* and DBx-T2* had good consistency (p > 0.05). There were proportional differences in T2* values measured by the other methods (p < 0.05), and none of them could be considered to have good consistency.ConclusionDB CMR T2* and BB CMR T2* can be interchangeable in the assessment of myocardial iron load in TM patients. However, DB CMR T2* is more stable and reliable.https://www.frontiersin.org/articles/10.3389/fmed.2025.1608870/fullcardiac magnetic resonancedark bloodbright bloodmyocardial T2*thalassemia |
| spellingShingle | Jixing Yi Min Wu Suzhen Wei Qiliang Huang Bumin Liang Peng Peng Tao Li Fengming Xu Comparative assessments of myocardial iron load in thalassemia patients between dark blood and bright blood MRI T2* techniques Frontiers in Medicine cardiac magnetic resonance dark blood bright blood myocardial T2* thalassemia |
| title | Comparative assessments of myocardial iron load in thalassemia patients between dark blood and bright blood MRI T2* techniques |
| title_full | Comparative assessments of myocardial iron load in thalassemia patients between dark blood and bright blood MRI T2* techniques |
| title_fullStr | Comparative assessments of myocardial iron load in thalassemia patients between dark blood and bright blood MRI T2* techniques |
| title_full_unstemmed | Comparative assessments of myocardial iron load in thalassemia patients between dark blood and bright blood MRI T2* techniques |
| title_short | Comparative assessments of myocardial iron load in thalassemia patients between dark blood and bright blood MRI T2* techniques |
| title_sort | comparative assessments of myocardial iron load in thalassemia patients between dark blood and bright blood mri t2 techniques |
| topic | cardiac magnetic resonance dark blood bright blood myocardial T2* thalassemia |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1608870/full |
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