Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010
ABSTRACT Bifidobacteria are key members of the human gut, especially during infancy. The ability of bifidobacteria to outcompete other members of the microbial communities encountered in this highly competitive human gut environment represents a key example of their evolutionary and ecological succe...
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | Microbial Biotechnology |
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| Online Access: | https://doi.org/10.1111/1751-7915.70189 |
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| _version_ | 1839612477013229568 |
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| author | Giulia Longhi Silvia Petraro Christian Milani Chiara Tarracchini Chiara Argentini Laura Maria Vergna Gabriele Andrea Lugli Leonardo Mancabelli Ciaran Lee Francesca Turroni Douwe vanSinderen Marco Ventura |
| author_facet | Giulia Longhi Silvia Petraro Christian Milani Chiara Tarracchini Chiara Argentini Laura Maria Vergna Gabriele Andrea Lugli Leonardo Mancabelli Ciaran Lee Francesca Turroni Douwe vanSinderen Marco Ventura |
| author_sort | Giulia Longhi |
| collection | DOAJ |
| description | ABSTRACT Bifidobacteria are key members of the human gut, especially during infancy. The ability of bifidobacteria to outcompete other members of the microbial communities encountered in this highly competitive human gut environment represents a key example of their evolutionary and ecological success. In the current report, we investigated the highly conserved bifidobacterial upp gene, which encodes the uracil phosphoribosyltransferase and which is involved in the pyrimidine salvage pathway. Phylogenetic analysis incorporating 107 bifidobacterial upp sequences, representing all currently known Bifidobacterium taxa, indicates that this gene followed an evolutionary route that apparently deviates from that of the 16S rRNA gene. In addition, the upp gene may support bifidobacterial survival in environments with limited uracil availability, potentially providing a competitive advantage under nutrient‐restricted conditions. |
| format | Article |
| id | doaj-art-554c258b80de4920ada14dcd9aa6e1a1 |
| institution | Matheson Library |
| issn | 1751-7915 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Microbial Biotechnology |
| spelling | doaj-art-554c258b80de4920ada14dcd9aa6e1a12025-07-28T07:44:42ZengWileyMicrobial Biotechnology1751-79152025-07-01187n/an/a10.1111/1751-7915.70189Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010Giulia Longhi0Silvia Petraro1Christian Milani2Chiara Tarracchini3Chiara Argentini4Laura Maria Vergna5Gabriele Andrea Lugli6Leonardo Mancabelli7Ciaran Lee8Francesca Turroni9Douwe vanSinderen10Marco Ventura11Laboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability University of Parma Parma ItalyLaboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability University of Parma Parma ItalyLaboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability University of Parma Parma ItalyLaboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability University of Parma Parma ItalyLaboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability University of Parma Parma ItalyLaboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability University of Parma Parma ItalyLaboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability University of Parma Parma ItalyDepartment of Medicine and Surgery University of Parma Parma ItalyAPC Microbiome Institute and School of Microbiology, Bioscience Institute National University of Ireland Cork IrelandLaboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability University of Parma Parma ItalyAPC Microbiome Institute and School of Microbiology, Bioscience Institute National University of Ireland Cork IrelandLaboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability University of Parma Parma ItalyABSTRACT Bifidobacteria are key members of the human gut, especially during infancy. The ability of bifidobacteria to outcompete other members of the microbial communities encountered in this highly competitive human gut environment represents a key example of their evolutionary and ecological success. In the current report, we investigated the highly conserved bifidobacterial upp gene, which encodes the uracil phosphoribosyltransferase and which is involved in the pyrimidine salvage pathway. Phylogenetic analysis incorporating 107 bifidobacterial upp sequences, representing all currently known Bifidobacterium taxa, indicates that this gene followed an evolutionary route that apparently deviates from that of the 16S rRNA gene. In addition, the upp gene may support bifidobacterial survival in environments with limited uracil availability, potentially providing a competitive advantage under nutrient‐restricted conditions.https://doi.org/10.1111/1751-7915.70189Bifidobacteriummicrobe‐microbe interactionmicrobiota |
| spellingShingle | Giulia Longhi Silvia Petraro Christian Milani Chiara Tarracchini Chiara Argentini Laura Maria Vergna Gabriele Andrea Lugli Leonardo Mancabelli Ciaran Lee Francesca Turroni Douwe vanSinderen Marco Ventura Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010 Microbial Biotechnology Bifidobacterium microbe‐microbe interaction microbiota |
| title | Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010 |
| title_full | Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010 |
| title_fullStr | Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010 |
| title_full_unstemmed | Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010 |
| title_short | Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010 |
| title_sort | genetic characterisation of the upp gene in bifidobacterium bifidum prl2010 |
| topic | Bifidobacterium microbe‐microbe interaction microbiota |
| url | https://doi.org/10.1111/1751-7915.70189 |
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