Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles
Postoperative cognitive dysfunction is a common central nervous system complication after general anesthesia in the elderly, and when it occurs, it will seriously affect the patient’s postoperative recovery and quality of life, which puts elderly postoperative general anesthesia patients at an extre...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1613378/full |
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| author | Yunmeng Zhang Zengsheng Yin Zhiyong Zou Shangzhi Feng Huayang Xu |
| author_facet | Yunmeng Zhang Zengsheng Yin Zhiyong Zou Shangzhi Feng Huayang Xu |
| author_sort | Yunmeng Zhang |
| collection | DOAJ |
| description | Postoperative cognitive dysfunction is a common central nervous system complication after general anesthesia in the elderly, and when it occurs, it will seriously affect the patient’s postoperative recovery and quality of life, which puts elderly postoperative general anesthesia patients at an extremely uncertain risk of postoperative psychiatric disorders or even death. It is currently believed that neuronal damage and inflammatory response due to cerebral ischemia/reperfusion injury induced by transient or repeated global cerebral ischemia during surgery are the key mechanisms for the development of postoperative cognitive dysfunction. Therefore, repairing postoperative neuronal damage and reducing neuroinflammatory responses may be an effective means of early intervention for postoperative cognitive dysfunction. Extracellular vesicles, a therapeutic tool with clear advantages in regenerative medicine, have been suggested as potential nanopathways to modulate postoperative cognitive dysfunction due to their pro-regenerative, pro-repair, and influence on immune responses. In this paper, we will summarize studies related to extracellular vesicles in the treatment of postoperative cognitive dysfunction and discuss the potential function of extracellular vesicles in nerve repair and inhibition of acute neurological inflammation, which will expand the therapeutic strategies for postoperative cognitive dysfunction and may represent the development of novel cell-free therapeutic pathways for modulating postoperative cognitive dysfunction. |
| format | Article |
| id | doaj-art-53b34df7b5fd4fa6b715c803f68ed1fe |
| institution | Matheson Library |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-53b34df7b5fd4fa6b715c803f68ed1fe2025-06-30T05:26:05ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-06-011310.3389/fcell.2025.16133781613378Nanopathways modulating postoperative cognitive dysfunction: extracellular vesiclesYunmeng Zhang0Zengsheng Yin1Zhiyong Zou2Shangzhi Feng3Huayang Xu4Department of Anesthesiology, Jiujiang College Hospital, Jiujiang, Jiangxi, ChinaDepartment of Anesthesiology, Jiujiang College Hospital, Jiujiang, Jiangxi, ChinaDepartment of Anesthesiology, Jiujiang College Hospital, Jiujiang, Jiangxi, ChinaDepartment of Urology, Jiujiang University Clinic College/Hospital, Jiujiang, Jiangxi, ChinaDepartment of Anesthesiology, Jiujiang College Hospital, Jiujiang, Jiangxi, ChinaPostoperative cognitive dysfunction is a common central nervous system complication after general anesthesia in the elderly, and when it occurs, it will seriously affect the patient’s postoperative recovery and quality of life, which puts elderly postoperative general anesthesia patients at an extremely uncertain risk of postoperative psychiatric disorders or even death. It is currently believed that neuronal damage and inflammatory response due to cerebral ischemia/reperfusion injury induced by transient or repeated global cerebral ischemia during surgery are the key mechanisms for the development of postoperative cognitive dysfunction. Therefore, repairing postoperative neuronal damage and reducing neuroinflammatory responses may be an effective means of early intervention for postoperative cognitive dysfunction. Extracellular vesicles, a therapeutic tool with clear advantages in regenerative medicine, have been suggested as potential nanopathways to modulate postoperative cognitive dysfunction due to their pro-regenerative, pro-repair, and influence on immune responses. In this paper, we will summarize studies related to extracellular vesicles in the treatment of postoperative cognitive dysfunction and discuss the potential function of extracellular vesicles in nerve repair and inhibition of acute neurological inflammation, which will expand the therapeutic strategies for postoperative cognitive dysfunction and may represent the development of novel cell-free therapeutic pathways for modulating postoperative cognitive dysfunction.https://www.frontiersin.org/articles/10.3389/fcell.2025.1613378/fullpostoperative cognitive dysfunctionextracellular vesiclenano-targeted therapyneuroinflammationneurorestorationcell-free therapeutic pathway |
| spellingShingle | Yunmeng Zhang Zengsheng Yin Zhiyong Zou Shangzhi Feng Huayang Xu Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles Frontiers in Cell and Developmental Biology postoperative cognitive dysfunction extracellular vesicle nano-targeted therapy neuroinflammation neurorestoration cell-free therapeutic pathway |
| title | Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles |
| title_full | Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles |
| title_fullStr | Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles |
| title_full_unstemmed | Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles |
| title_short | Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles |
| title_sort | nanopathways modulating postoperative cognitive dysfunction extracellular vesicles |
| topic | postoperative cognitive dysfunction extracellular vesicle nano-targeted therapy neuroinflammation neurorestoration cell-free therapeutic pathway |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1613378/full |
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