A clinical case of atopic dermatitis with a rapid positive effect from the use of a genetically engineered biological drug in a teenager
Introduction. The instructions for the drug dupilumab indicate that the administration of a single loading dose on the first day leads to the rapid achievement of clinically effective concentrations within 2 weeks, which we saw in the example of our patient and her real clinical response to the firs...
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| Language: | Russian |
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Association of Paediatric Allergists and Immunologists of Russia (APAIR)
2024-05-01
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| Series: | Аллергология и Иммунология в Педиатрии |
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| Online Access: | https://adair.elpub.ru/jour/article/view/128 |
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| author | E. V. Churyukina E. A. Portnyaga |
| author_facet | E. V. Churyukina E. A. Portnyaga |
| author_sort | E. V. Churyukina |
| collection | DOAJ |
| description | Introduction. The instructions for the drug dupilumab indicate that the administration of a single loading dose on the first day leads to the rapid achievement of clinically effective concentrations within 2 weeks, which we saw in the example of our patient and her real clinical response to the first injection. Presentation of a clinical case. Under our medical supervision was a 17-year-old patient with severe atopic dermatitis, resistant to traditional therapy. Heredity for allergic pathology is burdened: the girl’s mother suffers from pollen allergy. Initially before the start of therapy: SCORAD — 88 points, EASI — 48.8 points, IGA — 4, blood eosinophils — 11 % (1188 cells/ml), total IgE — 1102.0 IU/ml; the content of nitric oxide in exhaled air (FeNO) is 30 ppb. On April 28, 2021, the patient was administered dupilumab at a dose of 600 mg. Assessment of atopic dermatitis control in points upon admission to the hospital 2 weeks after the first administration of dupilumab: on the SCORAD scale — 44.5 points; EASI — 13.8 points; IGA — 2 points, eosinophils — 9 % (1070 cells/ml); total IgE — 840 IU/ml; FeNO — 5 ppb. Conclusion. This clinical observation clearly illustrates the fact that patients with severe atopic dermatitis who don’t respond to first-line therapy can achieve positive clinical results after the first use of a recombinant human monoclonal antibody (IgG4). |
| format | Article |
| id | doaj-art-529d2b0a4bfb4b1daaaafc81c6eeb47d |
| institution | Matheson Library |
| issn | 2500-1175 2712-7958 |
| language | Russian |
| publishDate | 2024-05-01 |
| publisher | Association of Paediatric Allergists and Immunologists of Russia (APAIR) |
| record_format | Article |
| series | Аллергология и Иммунология в Педиатрии |
| spelling | doaj-art-529d2b0a4bfb4b1daaaafc81c6eeb47d2025-08-03T13:01:11ZrusAssociation of Paediatric Allergists and Immunologists of Russia (APAIR)Аллергология и Иммунология в Педиатрии2500-11752712-79582024-05-0101202610.53529/2500-1175-2024-1-20-26103A clinical case of atopic dermatitis with a rapid positive effect from the use of a genetically engineered biological drug in a teenagerE. V. Churyukina0E. A. Portnyaga1Rostov State Medical University; Kuban State Medical UniversitySM-ClinicIntroduction. The instructions for the drug dupilumab indicate that the administration of a single loading dose on the first day leads to the rapid achievement of clinically effective concentrations within 2 weeks, which we saw in the example of our patient and her real clinical response to the first injection. Presentation of a clinical case. Under our medical supervision was a 17-year-old patient with severe atopic dermatitis, resistant to traditional therapy. Heredity for allergic pathology is burdened: the girl’s mother suffers from pollen allergy. Initially before the start of therapy: SCORAD — 88 points, EASI — 48.8 points, IGA — 4, blood eosinophils — 11 % (1188 cells/ml), total IgE — 1102.0 IU/ml; the content of nitric oxide in exhaled air (FeNO) is 30 ppb. On April 28, 2021, the patient was administered dupilumab at a dose of 600 mg. Assessment of atopic dermatitis control in points upon admission to the hospital 2 weeks after the first administration of dupilumab: on the SCORAD scale — 44.5 points; EASI — 13.8 points; IGA — 2 points, eosinophils — 9 % (1070 cells/ml); total IgE — 840 IU/ml; FeNO — 5 ppb. Conclusion. This clinical observation clearly illustrates the fact that patients with severe atopic dermatitis who don’t respond to first-line therapy can achieve positive clinical results after the first use of a recombinant human monoclonal antibody (IgG4).https://adair.elpub.ru/jour/article/view/128atopic dermatitisbiotherapydupilumab |
| spellingShingle | E. V. Churyukina E. A. Portnyaga A clinical case of atopic dermatitis with a rapid positive effect from the use of a genetically engineered biological drug in a teenager Аллергология и Иммунология в Педиатрии atopic dermatitis biotherapy dupilumab |
| title | A clinical case of atopic dermatitis with a rapid positive effect from the use of a genetically engineered biological drug in a teenager |
| title_full | A clinical case of atopic dermatitis with a rapid positive effect from the use of a genetically engineered biological drug in a teenager |
| title_fullStr | A clinical case of atopic dermatitis with a rapid positive effect from the use of a genetically engineered biological drug in a teenager |
| title_full_unstemmed | A clinical case of atopic dermatitis with a rapid positive effect from the use of a genetically engineered biological drug in a teenager |
| title_short | A clinical case of atopic dermatitis with a rapid positive effect from the use of a genetically engineered biological drug in a teenager |
| title_sort | clinical case of atopic dermatitis with a rapid positive effect from the use of a genetically engineered biological drug in a teenager |
| topic | atopic dermatitis biotherapy dupilumab |
| url | https://adair.elpub.ru/jour/article/view/128 |
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