Multi-Modal Analysis of Satellite Cells Reveals Early Impairments at Pre-Contractile Stages of Myogenesis in Duchenne Muscular Dystrophy

Multi-Modal Analysis of Satellite Cells Reveals Early Impairments at Pre-Contractile Stages of Myogenesis in Duchenne Muscular Dystrophy

Recent studies on myogenic satellite cells (SCs) in Duchenne muscular dystrophy (DMD) documented altered division capacities and impaired regeneration potential of SCs in DMD patients and animal models. It remains unknown, however, if SC-intrinsic effects trigger these deficiencies at pre-contractil...

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Bibliographic Details
Main Authors: Sophie Franzmeier, Shounak Chakraborty, Armina Mortazavi, Jan B. Stöckl, Jianfei Jiang, Nicole Pfarr, Benedikt Sabass, Thomas Fröhlich, Clara Kaufhold, Michael Stirm, Eckhard Wolf, Jürgen Schlegel, Kaspar Matiasek
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
DMD
dystrophin
muscle stem cells
porcine model
muscle pathology
transcriptomics
Online Access:https://www.mdpi.com/2073-4409/14/12/892
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