Study of inhalation micropowders obtained by spray drying
Objectives. To study the influence of the type of matrix-forming material and excipients concentration, spray drying parameters on the characteristics of the powder for inhalation, as well as to investigate the inhalation compositions for stability under stressful conditions.Methods. Spray drying wa...
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2024-09-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/2124 |
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| author | L. A. Shcherbakova A. I. Saitgareeva M. G. Gordienko R. R. Safarov |
| author_facet | L. A. Shcherbakova A. I. Saitgareeva M. G. Gordienko R. R. Safarov |
| author_sort | L. A. Shcherbakova |
| collection | DOAJ |
| description | Objectives. To study the influence of the type of matrix-forming material and excipients concentration, spray drying parameters on the characteristics of the powder for inhalation, as well as to investigate the inhalation compositions for stability under stressful conditions.Methods. Spray drying was used to obtain powder compositions with the required characteristics for inhalation therapy. Microscopic and analytical studies of powders were carried out. Statistical analysis made it possible to estimate the influence of factors on the powder characteristics and rank them by importance. The stability of spray dried powders was studied.Results. The optimal parameters for obtaining powders for inhalation were found by means of mathematical statistics: air flow rate was 37 m3/h; compressed air flow rate — 601 L/h; inlet air temperature — 150°C; solution flow rate — 45% of the power of the peristaltic pump (16.3 g/min for this composition); L-leucine concentration — 10 wt %; ratio of components of the matrix polyvinylpyrrolidone K-30/D-mannitol = 1 : 3. Under these conditions, as well as by means of 2 experiments additionally selected from the research design, a composition with isoniazid as an active substance was spray dried. The resulting powders were analyzed, in order to confirm the correctness of the recommended parameters.Conclusions. The selection of compositions and spray drying conditions involves multiple criteria. The characteristics of the powder for inhalation may deteriorate significantly during long-term storage. The optimal parameters were determined using statistical analysis and confirmed by experimental data. |
| format | Article |
| id | doaj-art-51bf47d3433e45aeb17d1350a9a997d7 |
| institution | Matheson Library |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2024-09-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-51bf47d3433e45aeb17d1350a9a997d72025-08-04T10:19:41ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752024-09-0119432733610.32362/2410-6593-2024-19-4-327-3361769Study of inhalation micropowders obtained by spray dryingL. A. Shcherbakova0A. I. Saitgareeva1M. G. Gordienko2R. R. Safarov3D.I. Mendeleev University of Chemical Technology of RussiaD.I. Mendeleev University of Chemical Technology of RussiaD.I. Mendeleev University of Chemical Technology of RussiaD.I. Mendeleev University of Chemical Technology of RussiaObjectives. To study the influence of the type of matrix-forming material and excipients concentration, spray drying parameters on the characteristics of the powder for inhalation, as well as to investigate the inhalation compositions for stability under stressful conditions.Methods. Spray drying was used to obtain powder compositions with the required characteristics for inhalation therapy. Microscopic and analytical studies of powders were carried out. Statistical analysis made it possible to estimate the influence of factors on the powder characteristics and rank them by importance. The stability of spray dried powders was studied.Results. The optimal parameters for obtaining powders for inhalation were found by means of mathematical statistics: air flow rate was 37 m3/h; compressed air flow rate — 601 L/h; inlet air temperature — 150°C; solution flow rate — 45% of the power of the peristaltic pump (16.3 g/min for this composition); L-leucine concentration — 10 wt %; ratio of components of the matrix polyvinylpyrrolidone K-30/D-mannitol = 1 : 3. Under these conditions, as well as by means of 2 experiments additionally selected from the research design, a composition with isoniazid as an active substance was spray dried. The resulting powders were analyzed, in order to confirm the correctness of the recommended parameters.Conclusions. The selection of compositions and spray drying conditions involves multiple criteria. The characteristics of the powder for inhalation may deteriorate significantly during long-term storage. The optimal parameters were determined using statistical analysis and confirmed by experimental data.https://www.finechem-mirea.ru/jour/article/view/2124spray dryingactive pharmaceutical ingredientmicropowdersinhalationexperiment planning methodsoptimization |
| spellingShingle | L. A. Shcherbakova A. I. Saitgareeva M. G. Gordienko R. R. Safarov Study of inhalation micropowders obtained by spray drying Тонкие химические технологии spray drying active pharmaceutical ingredient micropowders inhalation experiment planning methods optimization |
| title | Study of inhalation micropowders obtained by spray drying |
| title_full | Study of inhalation micropowders obtained by spray drying |
| title_fullStr | Study of inhalation micropowders obtained by spray drying |
| title_full_unstemmed | Study of inhalation micropowders obtained by spray drying |
| title_short | Study of inhalation micropowders obtained by spray drying |
| title_sort | study of inhalation micropowders obtained by spray drying |
| topic | spray drying active pharmaceutical ingredient micropowders inhalation experiment planning methods optimization |
| url | https://www.finechem-mirea.ru/jour/article/view/2124 |
| work_keys_str_mv | AT lashcherbakova studyofinhalationmicropowdersobtainedbyspraydrying AT aisaitgareeva studyofinhalationmicropowdersobtainedbyspraydrying AT mggordienko studyofinhalationmicropowdersobtainedbyspraydrying AT rrsafarov studyofinhalationmicropowdersobtainedbyspraydrying |