Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma

Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma

ABSTRACT Background Integrin glycosylation is one mechanism regulating the invasion and metastasis of malignant tumors. Little information exists about integrin glycosylation in head and neck squamous cell carcinoma (HNSCC). In this study, we evaluated the glycosylation of integrins in HNSCC tumor a...

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Main Authors: Erica Routila, Sadie Salminen, Randa Mahran, Mervi Toriseva, Heikki Irjala, Eeva Haapio, Eero Kytö, Sami Ventelä, Kim Pettersson, Johannes Routila, Kamlesh Gidwani, Janne Leivo
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Cancer Medicine
Subjects:
glycosylation
HNSCC
integrin
lectin
metastasis
therapy response
Online Access:https://doi.org/10.1002/cam4.70717
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