Physiology and clinical applications of GIP
Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells, primarily located in the upper small intestine, in response to food intake and plays a significant role in the postprandial regulation of nutrient metabolism. Although the importance of GIP in metabolic regula...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Japan Endocrine Society
2025-07-01
|
| Series: | Endocrine Journal |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/72/7/72_EJ25-0087/_html/-char/en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839646227477561344 |
|---|---|
| author | Shunsuke Yamane Norio Harada Nobuya Inagaki |
| author_facet | Shunsuke Yamane Norio Harada Nobuya Inagaki |
| author_sort | Shunsuke Yamane |
| collection | DOAJ |
| description | Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells, primarily located in the upper small intestine, in response to food intake and plays a significant role in the postprandial regulation of nutrient metabolism. Although the importance of GIP in metabolic regulation has long been recognized, progress in developing GIP as a therapeutic target has been limited. However, the GIP/GIP receptor (GIPR) axis has garnered increasing attention in recent years. Emerging evidence suggests that dual GIP/GLP-1 receptor agonists and triple GIP/GLP-1/glucagon receptor agonists provide beneficial metabolic effects in individuals with type 2 diabetes and obesity. In this review, we outline the physiological roles of GIP, detailing the mechanisms of GIP secretion from K cells in response to macronutrients, its actions on key target organs involved in metabolic regulation, and ongoing developments in its therapeutic applications. |
| format | Article |
| id | doaj-art-4fb8b813156d45d0a2117bc5087c3f08 |
| institution | Matheson Library |
| issn | 1348-4540 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-4fb8b813156d45d0a2117bc5087c3f082025-07-01T00:45:09ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402025-07-0172775176410.1507/endocrj.EJ25-0087endocrjPhysiology and clinical applications of GIPShunsuke Yamane0Norio Harada1Nobuya Inagaki2Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, JapanDepartment of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, JapanDepartment of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, JapanGlucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells, primarily located in the upper small intestine, in response to food intake and plays a significant role in the postprandial regulation of nutrient metabolism. Although the importance of GIP in metabolic regulation has long been recognized, progress in developing GIP as a therapeutic target has been limited. However, the GIP/GIP receptor (GIPR) axis has garnered increasing attention in recent years. Emerging evidence suggests that dual GIP/GLP-1 receptor agonists and triple GIP/GLP-1/glucagon receptor agonists provide beneficial metabolic effects in individuals with type 2 diabetes and obesity. In this review, we outline the physiological roles of GIP, detailing the mechanisms of GIP secretion from K cells in response to macronutrients, its actions on key target organs involved in metabolic regulation, and ongoing developments in its therapeutic applications.https://www.jstage.jst.go.jp/article/endocrj/72/7/72_EJ25-0087/_html/-char/englucose-dependent insulinotropic polypeptide (gip)incretinobesitydiabetes |
| spellingShingle | Shunsuke Yamane Norio Harada Nobuya Inagaki Physiology and clinical applications of GIP Endocrine Journal glucose-dependent insulinotropic polypeptide (gip) incretin obesity diabetes |
| title | Physiology and clinical applications of GIP |
| title_full | Physiology and clinical applications of GIP |
| title_fullStr | Physiology and clinical applications of GIP |
| title_full_unstemmed | Physiology and clinical applications of GIP |
| title_short | Physiology and clinical applications of GIP |
| title_sort | physiology and clinical applications of gip |
| topic | glucose-dependent insulinotropic polypeptide (gip) incretin obesity diabetes |
| url | https://www.jstage.jst.go.jp/article/endocrj/72/7/72_EJ25-0087/_html/-char/en |
| work_keys_str_mv | AT shunsukeyamane physiologyandclinicalapplicationsofgip AT norioharada physiologyandclinicalapplicationsofgip AT nobuyainagaki physiologyandclinicalapplicationsofgip |