Modification of low-density lipoproteins by low molecular weight carbonyl products of free-radical oxidation of lipids and carbohydrates plays a key role in atherosclerotic lesion of the vascular wall and in endothelial dysfunction
The review presents evidence of the participation of low-density lipoproteins (LDL) modified by low molecular weight dicarbonyl compounds formed during freeradical oxidation of lipids (malondialdehyde) and carbohydrates in the development of endothelial dysfunction and atherosclerotic vascular lesio...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2023-07-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/4204 |
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| author | V. Z. Lankin A. K. Tikhaze V. Ya. Kosach G. G. Konovalova A. V. Kudryashova |
| author_facet | V. Z. Lankin A. K. Tikhaze V. Ya. Kosach G. G. Konovalova A. V. Kudryashova |
| author_sort | V. Z. Lankin |
| collection | DOAJ |
| description | The review presents evidence of the participation of low-density lipoproteins (LDL) modified by low molecular weight dicarbonyl compounds formed during freeradical oxidation of lipids (malondialdehyde) and carbohydrates in the development of endothelial dysfunction and atherosclerotic vascular lesions. The authors believe that it is they, and not oxidized (hydroperoxide-containing) LDL, that are the main factors of pathogenesis. The role of dicarbonyl-modified LDL in LOX-1 dependent induction of processes leading to the development of endothelial dysfunction is discussed. The results of studies proving that damage to the glycocalyx (a layer of macromolecules that prevent the development of endothelial dysfunction) covering the luminal surface of the endothelium is caused by hyperproduction of reactive oxygen species. Ways of pharmacological correction of free-radical oxidation processes are discussed, due to which inhibition of atherogenesis and diabetogenesis can be achieved. |
| format | Article |
| id | doaj-art-4ea45fa6c78e4080adf44dc54d843ed7 |
| institution | Matheson Library |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| publishDate | 2023-07-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj-art-4ea45fa6c78e4080adf44dc54d843ed72025-07-28T14:03:30ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962023-07-0183142410.29413/ABS.2023-8.3.22575Modification of low-density lipoproteins by low molecular weight carbonyl products of free-radical oxidation of lipids and carbohydrates plays a key role in atherosclerotic lesion of the vascular wall and in endothelial dysfunctionV. Z. Lankin0A. K. Tikhaze1V. Ya. Kosach2G. G. Konovalova3A. V. Kudryashova4National Medical Research Centre of Cardiology named after Academician E.I. ChazovNational Medical Research Centre of Cardiology named after Academician E.I. ChazovNational Medical Research Centre of Cardiology named after Academician E.I. ChazovNational Medical Research Centre of Cardiology named after Academician E.I. ChazovNational Medical Research Centre of Cardiology named after Academician E.I. ChazovThe review presents evidence of the participation of low-density lipoproteins (LDL) modified by low molecular weight dicarbonyl compounds formed during freeradical oxidation of lipids (malondialdehyde) and carbohydrates in the development of endothelial dysfunction and atherosclerotic vascular lesions. The authors believe that it is they, and not oxidized (hydroperoxide-containing) LDL, that are the main factors of pathogenesis. The role of dicarbonyl-modified LDL in LOX-1 dependent induction of processes leading to the development of endothelial dysfunction is discussed. The results of studies proving that damage to the glycocalyx (a layer of macromolecules that prevent the development of endothelial dysfunction) covering the luminal surface of the endothelium is caused by hyperproduction of reactive oxygen species. Ways of pharmacological correction of free-radical oxidation processes are discussed, due to which inhibition of atherogenesis and diabetogenesis can be achieved.https://www.actabiomedica.ru/jour/article/view/4204malondialdehydemethylglyoxalendothelial dysfunctionglycocalyxlow density lipoproteinsfree radicalsatherosclerosisdiabetes mellitus |
| spellingShingle | V. Z. Lankin A. K. Tikhaze V. Ya. Kosach G. G. Konovalova A. V. Kudryashova Modification of low-density lipoproteins by low molecular weight carbonyl products of free-radical oxidation of lipids and carbohydrates plays a key role in atherosclerotic lesion of the vascular wall and in endothelial dysfunction Acta Biomedica Scientifica malondialdehyde methylglyoxal endothelial dysfunction glycocalyx low density lipoproteins free radicals atherosclerosis diabetes mellitus |
| title | Modification of low-density lipoproteins by low molecular weight carbonyl products of free-radical oxidation of lipids and carbohydrates plays a key role in atherosclerotic lesion of the vascular wall and in endothelial dysfunction |
| title_full | Modification of low-density lipoproteins by low molecular weight carbonyl products of free-radical oxidation of lipids and carbohydrates plays a key role in atherosclerotic lesion of the vascular wall and in endothelial dysfunction |
| title_fullStr | Modification of low-density lipoproteins by low molecular weight carbonyl products of free-radical oxidation of lipids and carbohydrates plays a key role in atherosclerotic lesion of the vascular wall and in endothelial dysfunction |
| title_full_unstemmed | Modification of low-density lipoproteins by low molecular weight carbonyl products of free-radical oxidation of lipids and carbohydrates plays a key role in atherosclerotic lesion of the vascular wall and in endothelial dysfunction |
| title_short | Modification of low-density lipoproteins by low molecular weight carbonyl products of free-radical oxidation of lipids and carbohydrates plays a key role in atherosclerotic lesion of the vascular wall and in endothelial dysfunction |
| title_sort | modification of low density lipoproteins by low molecular weight carbonyl products of free radical oxidation of lipids and carbohydrates plays a key role in atherosclerotic lesion of the vascular wall and in endothelial dysfunction |
| topic | malondialdehyde methylglyoxal endothelial dysfunction glycocalyx low density lipoproteins free radicals atherosclerosis diabetes mellitus |
| url | https://www.actabiomedica.ru/jour/article/view/4204 |
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