Recurrent Subcutaneous Phaeohyphomycosis with Bone Involvement after Kidney Transplant
Phaeohyphomycosis is the term used to describe infections due to dematiaceous fungi which can cause cutaneous, pulmonary, and sinus infection, especially in immunocompromised patients. A 32-year-old deceased donor renal transplant recipient presented 8 months posttransplant with subcutaneous nodule...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Indian Journal of Transplantation |
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| Online Access: | https://journals.lww.com/10.4103/ijot.ijot_87_23 |
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| author | Sandhya Suresh P. R. Appan Prakash Ramprasad Elumalai Jayakumar Matcha Manikantan Shekar Barathi Gunabooshanam |
| author_facet | Sandhya Suresh P. R. Appan Prakash Ramprasad Elumalai Jayakumar Matcha Manikantan Shekar Barathi Gunabooshanam |
| author_sort | Sandhya Suresh |
| collection | DOAJ |
| description | Phaeohyphomycosis is the term used to describe infections due to dematiaceous fungi which can cause cutaneous, pulmonary, and sinus infection, especially in immunocompromised patients. A 32-year-old deceased donor renal transplant recipient presented 8 months posttransplant with subcutaneous nodule in the epigastric region. Biopsy showed pigmented, septate hyphae and he received itraconazole for 2 months. Three years later, he noticed recurrence of nodule and multiple nodules in the right foot with a right leg ulcer. Magnetic resonance imaging of the right leg showed underlying bone involvement. He underwent excision of the lesions along with extensive surgical debridement for recurrent phaeohyphomycosis. Lesions persisted despite prolonged itraconazole therapy and reduction of immunosuppression. He also had acute graft dysfunction due to tacrolimus toxicity requiring dose reduction. This is an unusual case of phaeohyphomycosis highlighting the risk of recurrence and deep tissue involvement as well as the therapeutic challenges of this infection. |
| format | Article |
| id | doaj-art-4e13d14b1a6448d8b6a6b916a3fc7b4d |
| institution | Matheson Library |
| issn | 2212-0017 2212-0025 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Transplantation |
| spelling | doaj-art-4e13d14b1a6448d8b6a6b916a3fc7b4d2025-07-04T07:39:49ZengWolters Kluwer Medknow PublicationsIndian Journal of Transplantation2212-00172212-00252025-04-0119225625810.4103/ijot.ijot_87_23Recurrent Subcutaneous Phaeohyphomycosis with Bone Involvement after Kidney TransplantSandhya SureshP. R. Appan PrakashRamprasad ElumalaiJayakumar MatchaManikantan ShekarBarathi GunabooshanamPhaeohyphomycosis is the term used to describe infections due to dematiaceous fungi which can cause cutaneous, pulmonary, and sinus infection, especially in immunocompromised patients. A 32-year-old deceased donor renal transplant recipient presented 8 months posttransplant with subcutaneous nodule in the epigastric region. Biopsy showed pigmented, septate hyphae and he received itraconazole for 2 months. Three years later, he noticed recurrence of nodule and multiple nodules in the right foot with a right leg ulcer. Magnetic resonance imaging of the right leg showed underlying bone involvement. He underwent excision of the lesions along with extensive surgical debridement for recurrent phaeohyphomycosis. Lesions persisted despite prolonged itraconazole therapy and reduction of immunosuppression. He also had acute graft dysfunction due to tacrolimus toxicity requiring dose reduction. This is an unusual case of phaeohyphomycosis highlighting the risk of recurrence and deep tissue involvement as well as the therapeutic challenges of this infection.https://journals.lww.com/10.4103/ijot.ijot_87_23itraconazolephaeohyphomycosistransplant |
| spellingShingle | Sandhya Suresh P. R. Appan Prakash Ramprasad Elumalai Jayakumar Matcha Manikantan Shekar Barathi Gunabooshanam Recurrent Subcutaneous Phaeohyphomycosis with Bone Involvement after Kidney Transplant Indian Journal of Transplantation itraconazole phaeohyphomycosis transplant |
| title | Recurrent Subcutaneous Phaeohyphomycosis with Bone Involvement after Kidney Transplant |
| title_full | Recurrent Subcutaneous Phaeohyphomycosis with Bone Involvement after Kidney Transplant |
| title_fullStr | Recurrent Subcutaneous Phaeohyphomycosis with Bone Involvement after Kidney Transplant |
| title_full_unstemmed | Recurrent Subcutaneous Phaeohyphomycosis with Bone Involvement after Kidney Transplant |
| title_short | Recurrent Subcutaneous Phaeohyphomycosis with Bone Involvement after Kidney Transplant |
| title_sort | recurrent subcutaneous phaeohyphomycosis with bone involvement after kidney transplant |
| topic | itraconazole phaeohyphomycosis transplant |
| url | https://journals.lww.com/10.4103/ijot.ijot_87_23 |
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