Factors associated with post‑operative complications in oral carcinoma: Prospective study
Objective: Patients who require surgery to treat head and neck cancer are at higher risk of perioperative complications and this scenario is not different for patients with malignant tumors of the oral cavity. Thus, the objective of the present study was to identify preoperative prognostic factors r...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
|
| Series: | Brazilian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1808869425000539 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839655960578097152 |
|---|---|
| author | Paulo Victor Sola Gimenes Daniel Abreu Rocha Marco Aurélio Vamondes Kulcsar Claudio Roberto Cernea Leandro Luongo Matos |
| author_facet | Paulo Victor Sola Gimenes Daniel Abreu Rocha Marco Aurélio Vamondes Kulcsar Claudio Roberto Cernea Leandro Luongo Matos |
| author_sort | Paulo Victor Sola Gimenes |
| collection | DOAJ |
| description | Objective: Patients who require surgery to treat head and neck cancer are at higher risk of perioperative complications and this scenario is not different for patients with malignant tumors of the oral cavity. Thus, the objective of the present study was to identify preoperative prognostic factors related to postoperative complications in the surgical treatment of oral cancer. Methods: Prospective study with 43 consecutive squamous cell carcinomas of the oral cavity submitted to surgical treatment with curative intent. Results: Seventeen patients presented postoperative complications until the thirtieth day of follow-up, of which 17.6% required surgical reoperation. The most common complications were suture dehiscence and surgical site infections. Alcohol abuse (p = 0.004), pT4a tumors (p = 0.044), tumors with thickness greater than 10 mm (p = 0.002), patients with mGPS score 1 and 2 (p = 0.027) and flap reconstruction (p < 0.001) were associated with higher rates of postoperative complications. To the multivariate analysis, patients with tumor thickness greater than 10 mm (HR = 11,240; 95% CI 1,052–120,059; p = 0.045 ‒ logistic regression) and reconstructed with myocutaneous flap (HR = 18,415; 95% CI 1,849−183,359; p = 0.013 ‒ logistic regression) had a higher risk of developing postoperative complications. Conclusion: Tumor thickness greater than 10 mm or use of myocutaneous flaps in the reconstruction were the predictors of risk of postoperative complications in patients with squamous cell carcinoma of the oral cavity. Level of evidence: Level III. |
| format | Article |
| id | doaj-art-4dcbc4055c1f449eb56b0dc2ffb51ccd |
| institution | Matheson Library |
| issn | 1808-8694 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj-art-4dcbc4055c1f449eb56b0dc2ffb51ccd2025-06-25T04:50:48ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86942025-07-0191101610Factors associated with post‑operative complications in oral carcinoma: Prospective studyPaulo Victor Sola Gimenes0Daniel Abreu Rocha1Marco Aurélio Vamondes Kulcsar2Claudio Roberto Cernea3Leandro Luongo Matos4Universidade de São Paulo (USP), Faculdade de Medicina (FM), Hospital das Clínicas (HC), São Paulo, SP, BrazilUniversidade de São Paulo (USP), Faculdade de Medicina (FM), Hospital das Clínicas (HC), São Paulo, SP, BrazilUniversidade de São Paulo (USP), Faculdade de Medicina (FM), Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, SP, BrazilUniversidade de São Paulo (USP), Faculdade de Medicina (FM), Hospital das Clínicas (HC), São Paulo, SP, BrazilUniversidade de São Paulo (USP), Faculdade de Medicina (FM), Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, SP, Brazil; Corresponding author.Objective: Patients who require surgery to treat head and neck cancer are at higher risk of perioperative complications and this scenario is not different for patients with malignant tumors of the oral cavity. Thus, the objective of the present study was to identify preoperative prognostic factors related to postoperative complications in the surgical treatment of oral cancer. Methods: Prospective study with 43 consecutive squamous cell carcinomas of the oral cavity submitted to surgical treatment with curative intent. Results: Seventeen patients presented postoperative complications until the thirtieth day of follow-up, of which 17.6% required surgical reoperation. The most common complications were suture dehiscence and surgical site infections. Alcohol abuse (p = 0.004), pT4a tumors (p = 0.044), tumors with thickness greater than 10 mm (p = 0.002), patients with mGPS score 1 and 2 (p = 0.027) and flap reconstruction (p < 0.001) were associated with higher rates of postoperative complications. To the multivariate analysis, patients with tumor thickness greater than 10 mm (HR = 11,240; 95% CI 1,052–120,059; p = 0.045 ‒ logistic regression) and reconstructed with myocutaneous flap (HR = 18,415; 95% CI 1,849−183,359; p = 0.013 ‒ logistic regression) had a higher risk of developing postoperative complications. Conclusion: Tumor thickness greater than 10 mm or use of myocutaneous flaps in the reconstruction were the predictors of risk of postoperative complications in patients with squamous cell carcinoma of the oral cavity. Level of evidence: Level III.http://www.sciencedirect.com/science/article/pii/S1808869425000539Mouth neoplasmsPostoperative complicationsPrognosis |
| spellingShingle | Paulo Victor Sola Gimenes Daniel Abreu Rocha Marco Aurélio Vamondes Kulcsar Claudio Roberto Cernea Leandro Luongo Matos Factors associated with post‑operative complications in oral carcinoma: Prospective study Brazilian Journal of Otorhinolaryngology Mouth neoplasms Postoperative complications Prognosis |
| title | Factors associated with post‑operative complications in oral carcinoma: Prospective study |
| title_full | Factors associated with post‑operative complications in oral carcinoma: Prospective study |
| title_fullStr | Factors associated with post‑operative complications in oral carcinoma: Prospective study |
| title_full_unstemmed | Factors associated with post‑operative complications in oral carcinoma: Prospective study |
| title_short | Factors associated with post‑operative complications in oral carcinoma: Prospective study |
| title_sort | factors associated with post operative complications in oral carcinoma prospective study |
| topic | Mouth neoplasms Postoperative complications Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S1808869425000539 |
| work_keys_str_mv | AT paulovictorsolagimenes factorsassociatedwithpostoperativecomplicationsinoralcarcinomaprospectivestudy AT danielabreurocha factorsassociatedwithpostoperativecomplicationsinoralcarcinomaprospectivestudy AT marcoaureliovamondeskulcsar factorsassociatedwithpostoperativecomplicationsinoralcarcinomaprospectivestudy AT claudiorobertocernea factorsassociatedwithpostoperativecomplicationsinoralcarcinomaprospectivestudy AT leandroluongomatos factorsassociatedwithpostoperativecomplicationsinoralcarcinomaprospectivestudy |