Biomimetic Hydrogels for In Vitro Modelling of Nucleus Pulposus Degeneration: Effects of Extracellular Matrix Compositional Change on Physicochemical Properties and Cell Phenotype

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Biomimetic Hydrogels for In Vitro Modelling of Nucleus Pulposus Degeneration: Effects of Extracellular Matrix Compositional Change on Physicochemical Properties and Cell Phenotype

The intervertebral disc, an anatomical compartment interposed between vertebral bodies, plays a key role in spine flexibility and compression loading. It comprises three tissues: the nucleus pulposus, the annulus fibrosus, and the end plates. Degeneration-related changes in the extracellular matrix...

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Bibliographic Details
Main Authors:	Narjes Rashidi, Nicholas Dowell, Derek Covill, John Shepperd, Matteo Santin
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Series:	Journal of Functional Biomaterials
Subjects:	intervertebral disc degeneration nucleus pulposus ECM changes nucleus pulposus-mimicking hydrogels nucleus pulposus collagen–proteoglycan hydrogel in vitro model for degenerated nucleus pulposus
Online Access:	https://www.mdpi.com/2079-4983/16/7/253
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