Sulfhydrylated albumin mitigates Acetaminophen-induced liver injury by restoring the integrated H2S-albumin thiol antioxidant network

Sulfhydrylated albumin mitigates Acetaminophen-induced liver injury by restoring the integrated H2S-albumin thiol antioxidant network

Acetaminophen (APAP) overdose is the leading cause of acute liver failure and a major global health issue. APAP hepatotoxicity is primarily driven by oxidative stress resulting from the depletion of hepatic glutathione (GSH). Given that hydrogen sulfide (H2S) and albumin are crucial components of th...

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Bibliographic Details
Main Authors: Xin Wang, Yang Sui, Rui Jiang, Yijun Xu, Mika Suda, Jie Cheng, Yingyu Zhang, Zhuheng Shi, Jianglin Fan, Jian Yao
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
APAP-Induced liver injury (AILI)
Oxidative stress
Hydrogen sulfide
Sulfhydrylated albumin
Thiol antioxidant
Glutathione
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002873
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