EFFECTS OF CALCIUM ANTAGONISTS OF THE THIRD GENERATION IN PATIENTS WITH ARTERIAL HYPERTENSION AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Aim. To study antihypertensive efficacy and safety of amlodipine maleate as well as its influence on respiratory function, C reactive protein plasma level, glucose and lipid metabolism in patients with arterial hypertension (HT) and chronic obstructive pulmonary disease (COPD).Material and methods....
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/873 |
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| author | D. A. Yakhontov N. F. Balabanova |
| author_facet | D. A. Yakhontov N. F. Balabanova |
| author_sort | D. A. Yakhontov |
| collection | DOAJ |
| description | Aim. To study antihypertensive efficacy and safety of amlodipine maleate as well as its influence on respiratory function, C reactive protein plasma level, glucose and lipid metabolism in patients with arterial hypertension (HT) and chronic obstructive pulmonary disease (COPD).Material and methods. 50 patients with HT 1-3 grade and COPD I-II stage in remission were randomized into two groups. 31 patients of the first group were treated with amlodipine maleate (Stamlo-M) 5-10 mg/d alone or in combination. 19 patients of the second group received any other antihypertensive therapy except dihydropyridine calcium antagonists.Results. Amlodipine in combined therapy has high antihypertensive efficacy providing achievement of target blood pressure levels and improvement of 24-hour blood pressure profile. Amlodipine therapy improved respiratory function and reduced systolic blood pressure in pulmonary artery. Amlodipine has no negative influence on metabolic status, did not increase sympathetic activity, and reduced C reactive protein levels. It demonstrated good tolerability and safety.Conclusion. High antihypertensive efficacy, improvement of respiratory function, and safety allows recommending amlodipine maleate (Stamlo-M) for usage in hypertensive patients with COPD. |
| format | Article |
| id | doaj-art-4d40e83f22cf4b22a09e5f7e9848d8a0 |
| institution | Matheson Library |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-4d40e83f22cf4b22a09e5f7e9848d8a02025-07-03T07:28:28ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-016333934410.20996/1819-6446-2010-6-3-339-344872EFFECTS OF CALCIUM ANTAGONISTS OF THE THIRD GENERATION IN PATIENTS WITH ARTERIAL HYPERTENSION AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASED. A. Yakhontov0N. F. Balabanova1Novosibirsk state medical universityNovosibirsk state medical universityAim. To study antihypertensive efficacy and safety of amlodipine maleate as well as its influence on respiratory function, C reactive protein plasma level, glucose and lipid metabolism in patients with arterial hypertension (HT) and chronic obstructive pulmonary disease (COPD).Material and methods. 50 patients with HT 1-3 grade and COPD I-II stage in remission were randomized into two groups. 31 patients of the first group were treated with amlodipine maleate (Stamlo-M) 5-10 mg/d alone or in combination. 19 patients of the second group received any other antihypertensive therapy except dihydropyridine calcium antagonists.Results. Amlodipine in combined therapy has high antihypertensive efficacy providing achievement of target blood pressure levels and improvement of 24-hour blood pressure profile. Amlodipine therapy improved respiratory function and reduced systolic blood pressure in pulmonary artery. Amlodipine has no negative influence on metabolic status, did not increase sympathetic activity, and reduced C reactive protein levels. It demonstrated good tolerability and safety.Conclusion. High antihypertensive efficacy, improvement of respiratory function, and safety allows recommending amlodipine maleate (Stamlo-M) for usage in hypertensive patients with COPD.https://www.rpcardio.online/jour/article/view/873arterial hypertensionchronic obstructive pulmonary diseasecalcium antagonistsamlodipine |
| spellingShingle | D. A. Yakhontov N. F. Balabanova EFFECTS OF CALCIUM ANTAGONISTS OF THE THIRD GENERATION IN PATIENTS WITH ARTERIAL HYPERTENSION AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE Рациональная фармакотерапия в кардиологии arterial hypertension chronic obstructive pulmonary disease calcium antagonists amlodipine |
| title | EFFECTS OF CALCIUM ANTAGONISTS OF THE THIRD GENERATION IN PATIENTS WITH ARTERIAL HYPERTENSION AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_full | EFFECTS OF CALCIUM ANTAGONISTS OF THE THIRD GENERATION IN PATIENTS WITH ARTERIAL HYPERTENSION AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_fullStr | EFFECTS OF CALCIUM ANTAGONISTS OF THE THIRD GENERATION IN PATIENTS WITH ARTERIAL HYPERTENSION AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_full_unstemmed | EFFECTS OF CALCIUM ANTAGONISTS OF THE THIRD GENERATION IN PATIENTS WITH ARTERIAL HYPERTENSION AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_short | EFFECTS OF CALCIUM ANTAGONISTS OF THE THIRD GENERATION IN PATIENTS WITH ARTERIAL HYPERTENSION AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_sort | effects of calcium antagonists of the third generation in patients with arterial hypertension and concomitant chronic obstructive pulmonary disease |
| topic | arterial hypertension chronic obstructive pulmonary disease calcium antagonists amlodipine |
| url | https://www.rpcardio.online/jour/article/view/873 |
| work_keys_str_mv | AT dayakhontov effectsofcalciumantagonistsofthethirdgenerationinpatientswitharterialhypertensionandconcomitantchronicobstructivepulmonarydisease AT nfbalabanova effectsofcalciumantagonistsofthethirdgenerationinpatientswitharterialhypertensionandconcomitantchronicobstructivepulmonarydisease |