Arterial stiffness and endothelial function in the long-term period after a coronavirus disease 2019
Aim. To assess endothelial function and arterial stiffness over time in patients after hospitalization with coronavirus disease 2019 (COVID-19) and compare them with a control group.Material and methods. A total of 53 patients over 18 years of age were hospitalized for COVID-19 in June — August 2021...
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«FIRMA «SILICEA» LLC
2024-06-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5803 |
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| author | S. A. Bondar O. P. Rotar E. V. Moguchaya M. А. Boyarinova E. P. Kolesova E. Yu. Vasilyeva A. A. Mikhailova T. L. Karonova A. O. Konradi |
| author_facet | S. A. Bondar O. P. Rotar E. V. Moguchaya M. А. Boyarinova E. P. Kolesova E. Yu. Vasilyeva A. A. Mikhailova T. L. Karonova A. O. Konradi |
| author_sort | S. A. Bondar |
| collection | DOAJ |
| description | Aim. To assess endothelial function and arterial stiffness over time in patients after hospitalization with coronavirus disease 2019 (COVID-19) and compare them with a control group.Material and methods. A total of 53 patients over 18 years of age were hospitalized for COVID-19 in June — August 2021 was examined at two visits: the first — 10-16 months, the second — 14-23 months after discharge from the hospital. Control group included 53 patients from the ESSE-RF epidemiological study of a St. Petersburg population who did not have COVID-19, selected by sex, status of smoking, hypertension and type 2 diabetes. Endothelial function was assessed by the levels of vascular cell adhesion molecule 1 (VCAM-1) and von Willebrand factor (vWF) in plasma and the reactive hyperemia index (lnRHI) on the EndoPAT 2000 system. Carotid-femoral pulse wave velocity (cfPWV) was determined using the SphygmoCor device, while cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) — using the VaSera device.Results. The prevalence of endothelial vasomotor function disorders at the first and second visits in the active group did not differ significantly as follows: lnRHI £0,51 — 21% and 21%, cfPWV >10 m/s — 17% and 14%, and SLSI >9 — 28% and 34%, respectively. Plasma VCAM-1 levels were significantly higher during hospitalization than at the first and second visits — no differences were found between visits. The levels of lnRHI, vWF, cfPWV, CAVI, ABI at the first and second visits did not differ significantly. Post-COVID-19 patients differed from the control group only by a significantly higher ABI level at the second visit. According to the analysis of covariance, COVID-19 is associated with a CAVI increase at the first visit, as well as with an increase in ABI at both visits.Conclusion. The 1,5-2-year follow-up of patients after COVID-19, which required hospitalization, showed a decrease in the plasma endothelial dysfunction parameter VCAM-1. There is no changes in endothelial function and arterial stiffness over a period of time from 10-16 months to 14-23 months after hospitalization with COVID-19. |
| format | Article |
| id | doaj-art-4c2062bb2b8e4c5fb7b9ee190d88b94f |
| institution | Matheson Library |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2024-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
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| series | Российский кардиологический журнал |
| spelling | doaj-art-4c2062bb2b8e4c5fb7b9ee190d88b94f2025-08-04T13:00:32Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202024-06-0129610.15829/560-4071-2024-58034098Arterial stiffness and endothelial function in the long-term period after a coronavirus disease 2019S. A. Bondar0O. P. Rotar1E. V. Moguchaya2M. А. Boyarinova3E. P. Kolesova4E. Yu. Vasilyeva5A. A. Mikhailova6T. L. Karonova7A. O. Konradi8Almazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAim. To assess endothelial function and arterial stiffness over time in patients after hospitalization with coronavirus disease 2019 (COVID-19) and compare them with a control group.Material and methods. A total of 53 patients over 18 years of age were hospitalized for COVID-19 in June — August 2021 was examined at two visits: the first — 10-16 months, the second — 14-23 months after discharge from the hospital. Control group included 53 patients from the ESSE-RF epidemiological study of a St. Petersburg population who did not have COVID-19, selected by sex, status of smoking, hypertension and type 2 diabetes. Endothelial function was assessed by the levels of vascular cell adhesion molecule 1 (VCAM-1) and von Willebrand factor (vWF) in plasma and the reactive hyperemia index (lnRHI) on the EndoPAT 2000 system. Carotid-femoral pulse wave velocity (cfPWV) was determined using the SphygmoCor device, while cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) — using the VaSera device.Results. The prevalence of endothelial vasomotor function disorders at the first and second visits in the active group did not differ significantly as follows: lnRHI £0,51 — 21% and 21%, cfPWV >10 m/s — 17% and 14%, and SLSI >9 — 28% and 34%, respectively. Plasma VCAM-1 levels were significantly higher during hospitalization than at the first and second visits — no differences were found between visits. The levels of lnRHI, vWF, cfPWV, CAVI, ABI at the first and second visits did not differ significantly. Post-COVID-19 patients differed from the control group only by a significantly higher ABI level at the second visit. According to the analysis of covariance, COVID-19 is associated with a CAVI increase at the first visit, as well as with an increase in ABI at both visits.Conclusion. The 1,5-2-year follow-up of patients after COVID-19, which required hospitalization, showed a decrease in the plasma endothelial dysfunction parameter VCAM-1. There is no changes in endothelial function and arterial stiffness over a period of time from 10-16 months to 14-23 months after hospitalization with COVID-19.https://russjcardiol.elpub.ru/jour/article/view/5803covid-19endotheliumarterial stiffnessvcam-1von willebrand factor |
| spellingShingle | S. A. Bondar O. P. Rotar E. V. Moguchaya M. А. Boyarinova E. P. Kolesova E. Yu. Vasilyeva A. A. Mikhailova T. L. Karonova A. O. Konradi Arterial stiffness and endothelial function in the long-term period after a coronavirus disease 2019 Российский кардиологический журнал covid-19 endothelium arterial stiffness vcam-1 von willebrand factor |
| title | Arterial stiffness and endothelial function in the long-term period after a coronavirus disease 2019 |
| title_full | Arterial stiffness and endothelial function in the long-term period after a coronavirus disease 2019 |
| title_fullStr | Arterial stiffness and endothelial function in the long-term period after a coronavirus disease 2019 |
| title_full_unstemmed | Arterial stiffness and endothelial function in the long-term period after a coronavirus disease 2019 |
| title_short | Arterial stiffness and endothelial function in the long-term period after a coronavirus disease 2019 |
| title_sort | arterial stiffness and endothelial function in the long term period after a coronavirus disease 2019 |
| topic | covid-19 endothelium arterial stiffness vcam-1 von willebrand factor |
| url | https://russjcardiol.elpub.ru/jour/article/view/5803 |
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